Zyprexa side effects

Zyprexa is an antipsychotic pharmaceutical drug made by Eli Lilly and Co.

Zyprexa side effects - weight gain
The reason some antipsychotic drugs such as Zyprexa used to treat schizophrenia cause patients to gain a lot of weight is due to an  increase in activity of an enzyme called AMPK in cells in the part of the brain that regulates eating behavior. The increase in the AMPK enzyme occurs even with very little doses of the Zyprexa drug. The use of Zyprexa drug has been crimped by concerns over weight gain. For more information on weight loss.

Did FDA know about Zyprexa side effects of weight gain?
February 2007 - Dr. David Graham says U.S. lawmakers should investigate the Food and Drug Administration's handling of side effects linked to Eli Lilly and Co.'s antipsychotic medication, Zyprexa. FDA scientist Dr. David Graham told a congressional hearing the drugmaker and the agency knew "for a long time" about the risk of weight gain from Zyprexa that could trigger diabetes. While such side effects were eventually added to the drug's prescribing instructions, Graham testified it was not clear how the agency handled the information or made the decision to alter the label.

Zyprexa side effects - Black hairy tongue
Black hairy tongue associated with Zyprexa treatment: a case report.
Mt Sinai J Med. 2006 Oct;73(6):891-4. Tamam L, Annagur BB. Department of Psychiatry, Cukurova University Faculty of Medicine, Balcali, 01330 Adana, Turkey.
Zyprexa is an atypical antipsychotic drug approved for acute and long-term treatment of bipolar disorder. There are a number of uncommon side effects of Zyprexa such as oral cavity lesions. In addition to the relatively common side effect of dry mouth, several articles have reported an association between Zyprexa treatment and the development of oral lesions such as apthous stomatitis, pharyngitis, glossitis and oral ulceration. Although there are several cases in which the tongue was affected in conjunction with stomatitis or pharyngitis, we could not find a case report indicating a direct relationship between Zyprexa use and a tongue lesion. We present here the case of a patient with bipolar disorder, who developed recurrent black hairy tongue on two different occasions following the addition of Zyprexa to lithium treatment. In the present case, xerostomia (dry mouth), which is an adverse reaction of both Zyprexa and lithium, may have played a role in the development of black hairy tongue. All agents with a possible side effect of xerostomia may predispose patients to black hairy tongue, especially when they are administered in combination. To preclude the development of this complication with such drugs, extra time and effort should be given to improving oral hygiene.