Zantac side effects Ranitidine
Zantac is a pharmaceutical drug that blocks the action of histamine on stomach cells, and reduces stomach acid production. Zantac is useful in promoting healing of stomach and duodenal ulcers, and in reducing ulcer pain. Zantac has been effective in preventing ulcer recurrence when given in low doses for prolonged periods of time. In doses higher than that used in ulcer treatment, Zantac has been helpful in treating heartburn and in healing ulcer and inflammation of the esophagus resulting from acid reflux.
Zantac side effects
The drug Zantac has many side effects. Some of these include headache, malaise,
dizziness, sleep changes, blurred vision, agitation,
depression, and
hallucinations, rapid heart beat, premature ventricular beats,
constipation,
diarrhea, nausea or vomiting and abdominal discomfort. Slight liver damage may
be another possible Zantac side effect.
How Zantac works
Histamine is a natural chemical that stimulates the stomach cells to produce
acid. Zantac belongs to a class of medications, called H2-blockers, that
block the action of histamine on stomach cells, thus reducing stomach acid
production.
Zantac and allergy
Ranitidine (150 mg daily) inhibits wheal, flare, and itching reactions in
skin-prick tests.
Allergy Asthma Proc. 2007 Nov-Dec;28(6): Kupczyk M, Kupryś I,
Bocheńska-Marciniak M, Górski P, Kuna P. Department of Pneumonology and
Allergology, Medical University of Lodz, Lodz, Poland.
H(1)-receptor antagonists are known to suppress reactions in skin-prick tests (SPTs);
however, the effect of H2-receptor antagonists remains unclear. The aim of this
study was to determine the influence of Zantac ranitidine on wheal, flare, and
itching sensation in SPTs. Twenty-one atopic patients (5 women and 16 men) with
an average age of 28 were tested with histamine, codeine, negative control
solution, and standard allergen extracts. Ranitidine (150 mg daily), loratadine
(10 mg daily), or placebo were given to the volunteers for 5 days in a
double-blind manner with 14 days of washout period. There was no difference in
wheal, flare, and itching between SPTs performed after placebo and washout
period. The analysis revealed a statistically significant suppression of wheal
and flare by ranitidine and loratadine. We found a significant suppression of
itching induced by Zantac (reduction of 26%) and loratadine (29%) as compared
with placebo. Our data show a suppressive effect of Zantac on the wheal, flare,
and itching sensation in SPT. Because the sensitivity and specificity of skin
testing requires withholding medication that could change the skin reactivity,
it seems important to take into account the possible influence of H(2)-receptor
antagonists on allergy diagnosis and therapy.
Zantac interaction with aspirin
Effect of ranitidine on the antiplatelet effects of aspirin in healthy human
subjects.
Am J Cardiol. 2007 Jan 1; Lev EI, Ramabadran RS, Guthikonda S, Patel R, Kleiman
A, Granada JF, DeLao T, Kleiman NS. The Methodist Hospital Research Institute
and The Methodist DeBakey Heart Center, The Methodist Hospital, Houston, TX,
USA.
Aspirin is often taken with H2-receptor antagonists. In vitro data suggest that
certain antagonists, such as ranitidine, have inhibitory effects on platelet
function. There are no reports on the combined effect of aspirin and H2-receptor
antagonists on platelet function in humans. Therefore, this study's aim was to
evaluate the effects of aspirin, ranitidine, and their combination on platelet
function in humans. Ten healthy men aged 34 years received aspirin 325 mg/day
for 4 days followed by a 9-day washout period, 3 days of ranitidine Zantac
treatment (150 mg twice daily), and 4 days of dual-drug treatment. Zantac
appears to attenuate the antiplatelet effects of aspirin in healthy volunteers.
The most likely mechanism for these findings is a change in the absorption
conditions of aspirin in the presence of ranitidine.
Zantac side effects emails
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A.
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