Serrapeptase Serratiopeptidase supplement

Serrapeptase, an enzyme isolated from a microorganism in silkworm, is widely used in Japan for inflammatory conditions. For more serrapeptase information.

Serrapeptase 20,000 units 
Manufactured by a FDA approved and GMP certified facility.

The silkworm has serrapeptase (also known as Serratio Peptidase or serratiopeptidase), a proteolytic enzyme. This enteric coated serrapeptase product by Physician Formulas is of the highest quality available. It is manufactured by a FDA approved facility. You can be sure you are getting exactly what you pay for.

Serrapeptase or serratiopeptidase, isolated from the microorganism Serratia E15,  is naturally present in the silkworm intestine which allows the emerging moth to dissolve its cocoon. Clinical use of serrapeptase in Europe and Asia spans over twenty five years.

 

Supplement Facts
Serrapeptase - 200mg
     SerratioPeptidase
     (20,000 units enteric coated granules -  120,000 units per gram)

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Benefits

Arthritis
Is this supplement of benefit for those with arthritis?
   We have not seen research as an osteoarthritis treatment.

Serrapeptase Research Update
The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection.
J Bone Joint Surg Am. 2006 Jun;88(6):1208-14.Animal Research Laboratory, Marmara University School of Medicine, Istanbul, Turkey.
Infection around an implanted orthopaedic device is a devastating complication, and the treatment of infections involving slime-forming bacteria is especially difficult. The purpose of the present study was to evaluate the effectiveness of a proteolytic enzyme, serratiopeptidase, in the eradication of a periprosthetic infection in an in vivo animal model. In sixty Sprague-Dawley rats, the medullary canal of the right femur was drilled through the intercondylar notch and was inoculated with a Staphylococcus epidermidis strain (ATCC 35984) with a high slime-producing capacity. The cavity was filled with polymethylmethacrylate cement, and a Kirschner wire that had contact with the knee joint was inserted. None of the animals received any treatment for two weeks. Twenty rats were killed at two weeks after the inoculation in order to determine if the infection had become established. The remaining forty rats were randomized into two groups. One group received serratiopeptidase enzyme injections into the knee joint in addition to antibiotic therapy for four weeks, and the other group received intra-articular saline solution injections together with the same antibiotic therapy. The animals from both groups were killed two weeks after the end of therapy (on Day 56). The knee specimens were evaluated bacteriologically and histologically to determine the prevalence of persistent infection and the effects of the enzyme on local tissue. At two weeks, inoculated bacteria grew on culture of specimens from twelve (63.2%) of nineteen animals in the no-treatment group. Microbiological testing suggested that infection persisted in only one (5.6%) of eighteen animals in the serratiopeptidase-and-antibiotic group, whereas it was present in six (37.5%) of sixteen animals in the antibiotic-only group (p = 0.001). Histological evaluation showed similar results (kappa = 0.92). Serratiopeptidase was effective for eradicating infection caused by biofilm-forming bacteria in this experimental animal model. The antibiofilm property of the enzyme may enhance antibiotic efficacy in the treatment of staphylococcal infections.

Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease.
Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. Respirology. 2003 Sep;8(3):316-20.
The proteolytic enzyme serrapeptase  is widely used in clinical practice in Japan. We investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. This study was an open-labelled trial with a non-treatment control group. Patients were randomly assigned to oral treatment with and without SER 30 mg/day for 4 weeks. Patients collected sputum samples for about 4 h in the morning on the day the trial began and 4 weeks later. We measured the amount of sputum by weighing. Part of each sputum sample was weighed and then completely dried and reweighed. The percentage solid component, viscosity and elasticity of the sputum were measured. Mucociliary transportability index was measured using ciliated bovine trachea ex vivo. Sputum smears were also prepared to count sputum neutrophils. Patients' symptoms were assessed by a questionnaire that used a visual analogue scale. After 4 weeks of serrapeptase treatment, sputum weight in the morning, percentage solid component, viscosity and elasticity of sputum, sputum neutrophil count, frequency of coughing and frequency of expectoration significantly decreased. The mean mucociliary transportability index increased from 13 to 24. Serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.

Intestinal absorption of serrapeptase in rats.
Biotechnology Research Laboratories, Takeda Chemical Industries Ltd., Osaka, Japan. Biotechnol Appl Biochem. 1994 Aug;20 ( Pt 1):101-8.
A sensitive sandwich enzyme immunoassay (e.i.a.) for serrapeptase, an orally available anti-inflammatory proteinase, was established using affinity-purified anti-TSP rabbit IgG and its Fab' fragment conjugated with horseradish peroxidase as the first and the second antibodies respectively. Serrapeptase in the plasma was determined by the e.i.a. after its oral administration (100 mg/kg) to rats. The peak concentration was observed between 30 min and 2 h after administration. TSP in the plasma samples was trapped on a microtitre plate coated with the affinity-purified anti-serrapeptase rabbit IgG, and the hydrolysis of a synthetic fluorogenic substrate, butoxycarbonyl-Glu(benzyloxy)-Ala-Arg-4-methylcoumaryl-7-amide, by the trapped TSP was fluorometrically measured (proteinase assay). The values obtained by the e.i.a. and those obtained by the proteinase assay correlated well for various plasma samples. These results indicate that orally administered serrapeptase was absorbed from the intestinal tract and transferred into the circulation in an enzymically active form.

Serrapeptase pill questions
Q. Can I take serrapeptase pill with nattokinase pill together?
   A. We have not seen research with the combination of serrapeptase and nattokinase pills, hence we prefer not to mix the two at this time.

Q. Last month as i was about to take flight from Washington to London I had sudden lower back pain radiating to my buttocks. Four hours in flight i had numbness in my left foot and began to loose movement in my left foot. Arriving at London i had to be wheeled out and return to USA as i could not afford to sit tight for another 8 hours. upon arrival in USA went straight to hospital and mri revealed severe pinched nerve and lower disk prolapsed with path so narrowed that immediate surgery was performed on my lower spine and pinched nerve freed. Has serrapeptase been used to revive nerves and help bring back strength and life after surgery so I can walk again without the walker? i am being given physical therapy and my doctor and surgeon say i have a good chance but some other people discourage me. can serrapeptase help build up my dying nerve and revive it? Also is it too early after the surgery to use this enzyme. I ordered it and got a serrapeptase bottle of 120 pills of 5 mg each but am skeptical about using it.
   A. We have not seen any research on the use of serrapeptase enzyme for this kind of low back pain condition and surgery.

Q. I am 49 yo male who has hidradenitis suppurativa and recently diagnosed with abdominal aortic atherosclerosis and diverticulosis. I have read where serrapeptase has been used to treat some of theses diseases. I have also read that the LDL maybe elevated while taking the serrapeptase. What is your opinion? Would the serrapeptase help with any of these diseases? Would the serrapeptase exacerbate any of theses? Is there any medication that would prevent the LDL increase while taking the serrapeptase? I am obviously interested in controlling the inflammation and reducing the atherosclerosis.
   A. We have not seen any studies that indicate serrapeptase elevates LDL levels. Research with serrapeptase is limited and we don't know how effective it will be in the conditions you mention.

Q. I really want to try a serrapeptase supplement. I tried another brand (DR's Best) which gave me ulcer pain in the morning after taking two caps the day before. I had ulcer pain two years ago and stopped all NSAIDs. I have been pain free until I tried the two serrapeptase caps. Its really sad because I wanted to use it for my arthritis and sciatica not to aggravate ulcers. Is the Physician Formulas brand of serrapeptase free of these side effects? I researched all over the internet no one mentioned not to take if you have gastrointestinal disorders such as ulcers They all say there are no side effects. Except one combination enzyme which also contain eerrapeptase states on its label, "do not take
if you have any gastrointestinal disorders such as ulcers". (RejuvenZyme by Source Naturals).
   A. We don't have enough human studies to determine if serrapeptase causes abdominal discomfort or induces ulcers. Thus far we have not has anyone write to us regarding stomach pain after taking a serrapeptase enzyme. Very little is known about the clinical uses and side effects of serrapeptase enzyme supplements.

Q. Could you please tell me if a pregnant woman could take a serrapeptase product?
   A. We have not seen any studies with serrapeptase safety in women who are pregnant. Hence, we suggest that a woman who is pregnant not take this product unless her doctor believes it is necessary.

Q. I thought you might find my experience with serrapeptase of interest. I have long-standing hypothyroidism, high blood pressure, high triglycerides, high cholesterol, and borderline sugar. I also have had a real struggle with severe night time hip pain due to trochanteric bursitis, first in the left hip for about 4 years which finally resolved, and now in the right. Over the last few months I have taken three 100-tablet bottles (5 mg) of serrapeptase. I had pain relief at night within about 10-15 minutes, but it was of short duration so I took repeated dosages. The pain seemed to be getting worse but was relieved with the serrapeptase. For longer lasting relief I sometimes used enteric coated aspirin. About a week ago after reading an article about the weight-loss benefits of drinking hot water, tea, etc alternating with cold or room temperature water. The hot water is said to stimulate peristalsis to eliminate waste. That night I drank about 6-7 cups of hot water just before going to bed and, to my amazement and joy, I was able to sleep without pain through the night! I have continued to drink 3/4 cups of hot water before retiring and it continues to help. I ran out of my serrapeptase about 3-4 weeks ago and my regular supplier says she has been unable to get it. After reading your comments about pain being connected with taking the serrapeptase, I have a theory which may be of interest (or maybe not!). Is it possible that the pain is the result of accumulated, dissolved fibrin which collects in joints and/or muscle if the patient is not consuming sufficient water to flush it from the body. I still have the pain but it is not as severe and I am able to sleep without repeated pain meds. It will be interesting when I get a new supply of serrpeptase to see if the pain returns and is again relieved by drinking hot water.

Q. Has there been any research on or case studies of the use of serrapeptase and/or nattokinase in the management of disseminated intravascular coagulation (DIC)? My husband was recently diagnosed with this condition, the most likely trigger being something related to his aortic abnormalities or to the surgery and dacron used to repair his aortic aneurysm a year ago. In attempting to educate myself about DIC, my first reaction was that this sounded as if the clotting would be a prime indication for serrapeptase and/or nattokinase. But the other side of that coin is the low platelet count and potential for inadequate coagulation. My husband's hematologist has mentioned the possibility of using heparin down the road to manage the condition. I worry about the potentially blood-thinning effect of heparin.
I'm familiar with serrapeptase and nattokinase for use with other conditions, but have never seen DIC listed as a condition that would be helped by one or both of these enzymes. If there's any data (anecdotal or research-based) showing benefit to the more natural approach, my husband and I would like to be able to bring it to his hematologist's attention.
   A. As of December 2007, we are not aware of studies regarding serrapeptase or nattokinase in terms of their role in disseminated intravascular coagulation.

Q. Took serrapeptase 500 mg daily for two weeks and thought morning stiffness was lessen. Then took 500 mg twice daily and noticed clear improvement in stiffness. However, after 1 month experienced jaw pain which grew extreme and led to emergency dental appointment. Antibiotics ended problem. Nothing anything like this has happened to me before. Coincidence ? I'm reluctant to experiment. I think we should know more about serrapeptase enzyme and just how it works.
   A. There's a lot that we don't know about the use of serrapeptase supplements.

Q. Could you tell me if serrapeptase has caused nose bleeds in any of your users. I ask this because my husband is suddenly having nose bleeds after not having one for 30 years and he has only just started on serrapeptase this year. If you know of other cases, let us know, so we can stop taking it and prevent him from having to go in for surgery to repair the vessel that is bleeding.
Would appreciate an answer right away if at all possible as the nose bleeds are heavy and are happening several times a day.
   A. We have not had any reports of nose bleeds with serrapeptase. It is possible they have occurred but no one has ever emailed us with bleeding due to serrapeptase. Nose bleeds that are recurring need evaluation by an ear nose throat specialist and it is a good idea to stop the supplements until such evaluation.

Q. I have varicose veins and one side of my leg above my knee is red and swollen. Is the serrapeptase product appropriate to use or is there a better product?
   A. See varicose vein. We have not seen studies with serrapeptase for the treatment of varicose veins.

Q. Has any research shown improvement of Dupuytren's contractures with serrapeptase or natural pills?
   A. See Dupuytren's contracture information.

Have you had any results using serrapeptase for frozen shoulder?
   We have not tested it for this purpose and don't have any patient feedback.

I have been taking Serrapeptase for about 3 years now. I started taking it because I had adhesions from endometriosis and it helped significantly with that. I noticed that the inflammation in my joints diminished significantly when I took it, so much so that I could tell the difference if I missed a dose. Recently though my joints are swelling a lot and the arthritis symptoms are increasing at an alarming rate all over my body. I take a good multivitamin from my chiropractor. I have dysautonomia and take Flurinef to maintain an adequate blood volume and blood pressure. I’m wondering if the Flurinef isn’t contributing to the arthritis since it alters/enhances the electrolyte balance. If the calcium and magnesium levels are thrown off, then wouldn’t it exacerbate the progress of the arthritis? I would hate to think that it is leaching calcium out of my bones.

I am taking Serrapeptase. I read on a web-site, perhaps an answer given by Dr. Sahelian, that one should not take more than 1 tablet (20,000 IU) per day and only for 5 days per week, if one has had a stent implanted in a coronary artery. I don't recall if the stent was medicated or not. Can you tell me why only one 20,000 IU tablet must be consumed and not more? I do have 2 stents and I believe that both are medicated. If this is true, please tell me why only one is recommended or, can I can take 2 per day.
    The use of this product in the United States is relatively new, and since the full range of side effects is not known caution is being advised until a few more years pass to see if any untoward reactions will occur from higher dosages or frequencies. It may be safe to take this enzyme in higher dosages but doctors don't have enough studies or experience yet.

Can you please tell me why a serrapeptase enzyme includes 46 mg of Calcium? I think yours is the first brand I've noticed that has this in it.
    The manufacturer felt it would stabilize the enzyme.

I am presently taking a serrapeptase brand that has no preservatives and is in capsule form. I notice on your info page you show a bottle of serrapeptase as 60 capsules and yet on the order page it is only available in the tablets. Why is it not available in capsules anymore? Also, could you set my mind at ease about the preservatives in your serrapeptase tablets such as silicon dioxide and magnesium stearate? Are these preservatives safe?
    Yes, the preservatives are safe and have been used for decades.

I plan on buying your serrapeptase after I use up the present brand I am using. I am aware that this enzyme must be taken on a empty stomach with no food, but what I need to know is if it also should not be taken with any other supplement such as coenzyme B-complex and chelated magnesium (which I also have to take on an empty stomach)?
    Perhaps they can be taken at different times of the morning, but it is not crucial, you may wish to try them together and separately to see if there are any differences in your particular case. Such interaction or absorption studies with combinations are not available at this time.

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