Royal jelly allergy
Caution: certain individuals may have allergic reactions to royal jelly.

Nutritional composition of royal jelly
Royal Jelly is a milk like secretion made by worker bees in the hive. It is so named because it serves as the sole food for the queen bee. It supplies B-vitamins, vitamins A, C, D, E & K, more than a dozen key minerals. amino acids, and other important constituents, including nucleic acids (DNA and RNA). Up to 50% (dry mass) of royal jelly is protein.

Health benefit of royal jelly
Royal jelly has potential health benefits such as antitumor, antibacterial, cholesterol lowering, antiinflammatory, and immune influencing properties. Royal jelly is beginning to be studied as a supplement that can influence the health of patients with Graves' disease. Royal jelly, as a whole or some of its individual components, stimulates production of type I collagen and other activities for bone formation through action on osteoblasts.

Royal jelly antibiotic effect
Additive activity of royal jelly and honey against Pseudomonas aeruginosa.
Altern Med Rev. 2008 Dec; Boukraa L. Department of Veterinary Sciences; faculty of Agro-Veterinary Sciences, Ibn-Khaldoun University of Tiaret, Algeria.
As natural products garner attention in the medical field, the emergence of antibiotic-resistant strains of bacteria has confounded the current use of antibiotic therapy, leading to the re-examination of earlier remedies such as honey and royal jelly. Four varieties of honey and one variety of freshly reaped royal jelly were used to evaluate the additive antimicrobial action against Pseudomonas aeruginosa (ATCC 27853). Initially, honey and royal jelly were used separately to determine their minimum inhibitory concentration (MIC) against the tested strain. Next, sub-MIC concentrations of honey and royal jelly were incorporated into media to determine the minimum additive inhibitory concentration. When tested separately, the MIC of the four varieties of honey ranged from 12-18 percent (volume/volume; v/v), and that of royal jelly was 4 percent (v/v). When combined with royal jelly, each honey variety tested showed a greater than 90-percent drop in MIC.

Royal jelly and breast cancer
Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells.
Biosci Biotechnol Biochem. 2007 Jan;71(1):253-5. Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan.
Royal jelly is known as a functional food containing many useful minerals. In this study, we found an anti-environmental estrogen activity of royal jelly. Bisphenol A is an environmental estrogen that stimulates proliferation of human breast cancer MCF-7 cells. Royal jelly inhibited the growth-promoting effect of Bisphenol Aon MCF-7 cells, even though it did not affect the proliferation of cells in the absence of Bisphenol A. In addition, this inhibiting effect of royal jelly was heat-stable.

Royal jelly and blood pressure in rodents
Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats.
Acta Med Okayama. 2009 Feb; Takaki-Doi S, Hashimoto K, Yamamura M, Kamei C. Department of Research and Development, Yamada Apiculture Center, Inc., Kagamino, Okayama 708-0393, Japan.
Angiotensin I-converting enzyme (ACE) inhibitory and hypotensive effects of 7 peptide fractions of royal jelly protein hydrolysate were studied in comparison with those of royal jelly protein hydrolysate alone. The long-lasting hypotensive effect of oral administration of royal jelly protein hydrolysate is dependent on the molecular weights of its ACE inhibitory peptides and the time required to digest them.

Royal jelly and osteoporosis
Royal jelly has been used worldwide for many years as medical products, health foods and cosmetics. Royal jelly contains testosterone and has steroid hormone-type activities and has been found in rodent studies to improve bone strength.

Royal jelly long term effects on rodents
Effects of long-term administration of royal jelly on pituitary weight and gene expression in middle-aged female rats.
Biosci Biotechnol Biochem. 2009 Feb; Narita Y, Ohta S, Suzuki KM, Nemoto T, Abe K, Mishima S. Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan.
To determine the effects of ingested royal jelly on the pituitary in middle-aged female rats, we performed a long-term royal jelly administration test. Several animals showed age-related increases in pituitary weight, and royal jelly administration compensated for the increase. royal jelly tended to down-regulate prolactin mRNA and up-regulated thyroid-stimulating hormone beta mRNA in the pituitary. This suggests that royal jelly compensates for age-associated decline in pituitary functions.

Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage.
IExp Gerontol. 2003 Sep;38(9):965-9.
In this study, we investigate the effect of dietary royal jelly on tissue DNA oxidative damage and on the life span of C3H/HeJ mice. In C3H/HeJ mice that were fed a dietary supplement of RJ for 16 weeks, the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, were significantly reduced in kidney DNA and serum. Secondly, we determined the effect of dietary RJ on the life span in C3H/HeJ mice. The 50% mice survivals of intermediate- (about 6 mg/kg weight) and high-dose groups (about 60 mg/kg weight) were reached at significantly longer times than that of the control group according to the generalized Wilcoxon test (p<0.05). The average survival times were 88 weeks for the control group vs. 79 weeks for the low-dose group (about 0.6 mg/kg weight), 112 weeks for the intermediate-dose group and 110 weeks for the high-dose group, respectively, showing that RJ extended the average survival time by about 25% compared to the control group. However, RJ did not extend the total life span. These results indicated that dietary RJ increased the average life span of C3H/HeJ mice, possibly through the mechanism of reduced oxidative damage.

Royal jelly antifungal activity
Efficacy of royal jelly against the oxidative stress of fumonisin in rats.
Toxicon. 2007 Aug;50(2):256-69. Food Toxicology and Contaminants Department, National Research Center, Dokki, Cairo, Egypt.

Fumonisins are mycotoxins produced by Fusarium verticillioides, frequently associated with corn. It produces toxicity, including teratogenicity, equine leukoencephalomalacia, porcine pulmonary edema, hepatic or renal damage in most animal species and perturb sphingolipid metabolism. The aim of the present study was to evaluate the protective effects of royal jelly against fumonisins toxicity. Sixty male Sprague-Dawley rats were divided into six treatment groups including the control group; group fed fumonisins -contaminated diet (200mg/kg diet) and the groups treated orally with royal jelly (100 or 150mg/kg body weight) with or without fumonisins for 3 weeks. It could be concluded that royal jelly have a protective effects against fumonisins toxicity and this protection was dose dependent.

Royal jelly and the immune system
Fatty acids from royal jelly have an influence on the immune system. How this influences health and disease in humans remains to be evaluated.

Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro.
Int Immunopharmacol. 2007 Sep;7(9):1211-20. Institute of Medical Research, MMA, Belgrade, Crnotravska 17, 11002 Belgrade, Serbia.
Researchers in Belgrade, Serbia, studied the effect of 10-hydroxy-2-decanoic acid (10-HDA) and 3,10-dihydroxy-decanoic acid (3,10-DDA), isolated from royal jelly, on the immune response using a model of rat dendritic cell (DC)-T-cell cocultures. Both fatty acids, at higher concentrations, inhibited the proliferation of allogeneic T cells. The effect of 10-HDA was stronger and was followed by a decrease in interleukin-2 (IL-2) production and down-regulation of IL-2 receptor expression. Spleen DC, cultivated with 10 microg/ml of fatty acids down-regulated the expression of CD86 and the production of IL-12, but up-regulated the production of IL-10. In contrast, DC, pretreated with 100 microg/ml of 3,10-DDA, up-regulated the expression of CD86 and augmented the proliferation of allogeneic T cells. The highest dose (200 microg/ml) of both fatty acids which was non-apoptotic for both T cells and DC, down-regulated the expression of MHC class II and CD86, decreased the production of IL-12 and made these DC less allostimulatory. The immunosuppressive activity of 3,10-DDA was also confirmed in vivo, using a model of Keyhole lymphet hemocyanine immunization of rats. In conclusion, our results showed the immunomodulatory activity of royal jelly fatty acids and suggest that DC are a significant target of their action.

Royal Jelly for tympanic membrane ear drum health
Effectiveness of royal jelly on tympanic membrane perforations: an experimental study.
J Otolaryngol Head Neck Surg. 2008 Apr; Calli C, Tugyan K, Oncel S, Pinar E, Demirtaşoglu F, Calli AO, Tolon B, Yilmaz O, Kiray A. Department of Head and Neck Surgery, Izmir Ataturk Training Hospital, Izmir, Turkey.
The aim of this study was to evaluate the comparison of the efficacy of royal jelly in a guinea pig tympanic membrane perforation model with untreated and control groups. Each animal underwent subtotal removal of the tympanic membrane in one ear. Animals were divided into two groups of eight animals each. Group A was treated with topical royal jelly, and group B was treated with saline. All opposite right ears were used as the control group. There was no significant difference between group A and group B in the incidence of perforation closure. There was no significant difference between group A and group B in the incidence of perforation closure. However, after 3 months, the mean thickness of the tympanic membranes was 0.11, 0.07, and 0.08 mm, respectively, in group A, group B, and the control. These results showed a statistically significant difference. Histologically, the tympanic membranes of group A showed marked fibroblastic orientation and well-organized connective tissue. Application of royal jelly improved the success rate of closure, as shown in the present study.This is the first study to investigate the effectiveness of royal jelly in enhancing healing in tympanic membrane perforations. Our study suggests that royal jelly is effective in increasing healing of tympanic membrane perforations in guinea pigs.

Royal jelly supplement emails
Q. if I have asthma when young but recovered, can I take royal jelly supplement?
   A. Asthma has many causes. Each person is different. A few people have an allergy to royal jelly but most people do not. We cannot advise you to take or not to take a royal jelly supplement, but you doctor may wish to read the info on this topic and guide you.

Q. Thanks for all the clear info on royal jelly. I bought a 7 oz jar of Royal Jelly that I never opened. It's been kept in the refrigerator for at least 8-9 months and still has the plastic seal around the top. I bought it for internal use. Is it still OK to take as a supplement? Can I still use it on my skin? How long can I keep it?
   A. You may wish to ask the manufacturer who knows better about the expiration date of that particular batch.

My question concerns Royal Jelly being able to normalize a woman’s hormones much like maca, Can you explain … could this be a better way than maca or HRT ?
    We have not seen such studies regarding the use of this supplement and its influence on hormone levels, so it is difficult to say.



 

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