Ribose pill and athletic performance - supplementation information
For energy and muscle, heart tissue
Ribose is a carbohydrate, or sugar, used by all living cells and is an essential
component in our body’s energy production.
Ribose has many important roles in physiology. Among them, ribose is a
necessary substrate for synthesis of nucleotides, and it is part of the building blocks
that form DNA and RNA molecules. The claim made is that ribose enhances athletic
performance. As of March 2009,
we
have not seen any
data to support that ribose is a beneficial nutrient for athletes. We
will update this page as more studies become available.
For more up to date
ribose research.
D Ribose, Source Naturals
* Fruit Flavored
* Dietary Supplement
During strenuous exercise, large amounts of ATP, the body's primary
energy-carrying molecule, can be depleted in heart and skeletal muscle cells.
D-Ribose is a simple sugar that is used by the body to synthesize nucleotides,
ATP, nucleic acids, and glycogen.*
Supplement Facts
D-Ribose - 3 grams per 3 chewable tablets
Click here to buy Ribose supplement product.
Benefits
Patients with chronic fatigue syndrome given D-ribose at a dose of 5 grams three
times a day for a total of 280 grams showed improvement in energy levels. This
regimen also helped in those with fibromyalgia..
Oral ribose supplementation with 4 g doses four times a day does not
help postexercise muscle ATP recovery and maximal intermittent exercise performance.
Ribose may help some individuals with
chronic fatigue
syndrome or those with
fibromyalgia. Ribose does not help patients with McCardle's disease.In patients with coronary artery disease, administration of ribose by
mouth for 3 days improved the heart's tolerance to ischemia.
There is no research published in peer-reviewed journals that shows ribose improves
athletic performance.
Ribose and athletic performance
Oral ribose supplementation with 4-g doses four times a day does not
help postexercise muscle ATP recovery and maximal intermittent exercise performance.
There have been claims that ribose supplements increase ATP levels and improve
athletic performance. Most studies show lack of effectiveness of ribose as an
ergogenic aid at high doses.
Ribose versus
dextrose supplementation, association with rowing performance: a double-blind
study.
Clin J Sport Med. 2006 Jan;16(1):68-71. Dunne L, Worley S, Macknin M. Sports
Medicine Center, Ohio State University, Columbus, OH, USA.
We compared the effects of ribose versus dextrose on rowing performance. We
studied the effects of ribose versus dextrose supplementation (10 g each in 8 oz
water) for 8 weeks before and after practice and 2000-m time trials. In the time
trials, the dextrose group showed significantly more improvement at 8 weeks than
the ribose group. We doubt ribose impaired, and hypothesize dextrose enhanced,
rowing performance. Further research is needed to define what role, if any,
dextrose and ribose play as athletic supplements.
Effects of ribose as an ergogenic aid.
J Strength Cond Res. 2006 Aug;20(3):519-22. Peveler WW, Bishop PA, Whitehorn
EJ. Department of Health and Kinesiology, Mississippi University for Women,
Columbus, MS 39701, USA.
There have been claims that ribose supplements increase ATP levels and improve
performance. Other studies have provided mixed results on the effectiveness of
ribose as an ergogenic aid at high doses. None of these studies have compared
the impact of the recommended dose of ribose on athletes and nonathletes under
exercise conditions that are most conducive for effectiveness. The purpose of
this study was to evaluate the effectiveness of ribose as an ergogenic aid at
the dose recommended for supplements currently on the market during an exercise
trial to maximize its efficacy. Male subjects (n = 11) performed 2 trials 1 week
apart. Each trial consisted of three 30-second Wingate tests with a 2-minute
recovery between each test. Trials were counterbalanced, with 1 trial being
performed with 625 mg of ribose and the other with a placebo. Peak power, mean
power, and percent decrease in power were recorded during each Wingate test.
Repeated-measures analysis of variance (p > 0.05) found no significant
differences between ribose and placebo. These results suggest that ribose had no
effect on performance when taken orally, at the dose suggested by the
distributor.
Effect of
ribose supplementation on resynthesis of adenine
nucleotides after intense intermittent training in humans.
Hellsten Y. Institute for Excersize and
Sport Science, DK-2100 Copenhagen, Denmark. yhellsten@aki.ku.dk
Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R182-8.
The effect of oral ribose supplementation on the resynthesis of adenine
nucleotides and performance after 1 wk of intense intermittent exercise was
examined. Eight subjects performed a random double-blind crossover design. The results support
the hypothesis that the availability of ribose in the muscle is a limiting
factor for the rate of resynthesis of ATP. Furthermore, the reduction in muscle
ATP observed after intense training does not appear to be limiting for
high-intensity exercise performance.
Effects of oral D-ribose supplementation on
anaerobic capacity and selected metabolic markers in healthy males.
Kreider RB,. Baylor University, Waco, TX 76798-7313, USA.
Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):76-86.
Oral D-ribose supplementation has been reported to increase adenine nucleotide
synthesis and exercise capacity in certain clinical populations. Theoretically,
increasing adenine nucleotide availability may enhance high intensity exercise
capacity. This study evaluated the potential ergogenic value of D-ribose
supplementation on repetitive high-intensity exercise capacity in 19 trained
males. Subjects were familiarized to the testing protocol and performed two
practice-testing trials before pre-supplementation testing. Each test involved
warming up for 5 min on a cycle ergometer and then performing two 30-s Wingate
anaerobic sprint tests on a computerized cycle ergometer separated by 3 min of
rest recovery. In the pre- and post-supplementation trials, blood samples were
obtained at rest, immediately following the first and second sprints, and
following 5 min of recovery from exercise. Subjects were then matched according
to body mass and anaerobic capacity and assigned to ingest, in a randomized and
double blind manner, capsules containing either 5 g of a dextrose placebo (P) or
D-ribose (R) twice daily (10 g/d) for 5 d. Subjects then performed
post-supplementation tests on the 6th day. Data were analyzed by ANOVA for
repeated measures. Results revealed a significant interaction (p =.04) in total
work output. Post hoc analysis revealed that work significantly declined during the second post-supplementation sprint in the P group while
being maintained in the R group. No significant interactions
were observed in peak power, average power, torque, fatigue index, lactate,
ammonia, glucose, or uric acid. Results indicate that oral ribose
supplementation (10 g/d for 5 d) does not affect anaerobic exercise capacity or
metabolic markers in trained subjects as evaluated in this study.
Ribose for chronic fatigue
Ribose may help some individuals with
chronic fatigue
syndrome or those with
fibromyalgia.
Ribose for heart disease
In patients with coronary artery disease, administration of ribose by
mouth for 3 days improves cardiac tolerance to ischemia.
Ribose supplementation and
mental fatigue
Effects of oral administration of caffeine and D-ribose on mental fatigue.
Nutrition. 2008 March.
We examined the effects of administering two different candidate antifatigue
substances, caffeine and D-ribose, on mental fatigue. In a double-blinded,
placebo-controlled, three-way crossover design, 17 healthy volunteers were
randomized to oral caffeine (200 mg/d), D-ribose (2000 mg/d), or placebo for 8
d. As fatigue-inducing mental tasks, subjects performed a 30-min Uchida-Kraepelin
psychodiagnostic test and a 30-min advanced trail-making test on four occasions.
Supplementation with D-ribose had no benefit or effect.
Comments: D ribose supplementation at 2 grams was not effective for
mental fatigue. Perhaps higher dosage may have an effect.
Ribose supplementation questions
Q. My dad is 80 and has had a kidney removed due to a benign tumor. His energy
level is sometimes very low as a result. I'm thinking ribose supplementation may
help that. Is there any contraindication in kidney patients I should be aware
of, using ribose pills?
A. We have not seen studies regarding ribose supplementation and
its effect on kidney function.
Q. I am taking
ribose for heart damage
from a stroke. Do you think creatine would be better?
A. We have no way of predicting whether creatine or ribose would be
helpful for your particular condition.
Q. I took ribose supplement and could tell an improvement in cardiac irritability in 15 minutes after 4.5 grams D-Ribose. Ectopic beats ceased after 30 minutes, and no further episodes of SVT supra ventricular tachycardia (Have been having episodic SVT bursts, and A. Fib. for past ten years lasting 4-12 hours per episode). Ran out of D-Ribose for 36 hours until shipment came in today and ectopic beats resumed 30 hours after last dose. Again ectopics ceased 30 minutes after resuming D-Ribose.
Q. I'm trying the product Ribose Muscle Edge. My mom heard about it on the Oprah
show with Dr. Oz, who spoke highly of this ribose Supplement. I'm trying it for
my bad bad Fibromyalgia and CFS. So I went and bought the ribose powder 100
grams and it says 1-3 scoops before of after work out. My work out is walking.
My question is. o I put it in water? Juice? Over something. I have looked and
looked for how to take it and have found nothing.
A. We are not familiar with Ribose Muscle Edge ribose supplement in
particular, but ribose powder in general can be mixed with juice.
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