Resveratrol
capsule antioxidant in wine - What is the right dosage to take?
Resveratrol is a dietary constituent found
in grapes and wine. Resveratrol exerts a wide variety of pharmacological
activities. Because the grape skins are not fermented in the production process
of white wines, only red wines contain considerable amounts of this compound.
Resveratrol is a phytoalexin, antibacterial and anti-fungal chemical that is
produced by several plants as a defense against infection by pathogens. Does
resveratrol supplement use lead to a longer life? The answers are not yet in but
many scientists are optimistic.
Resveratrol 10 mg, Club Natural,
Resveratrol
( trans-3,5,4'-trihydroxystilbene ) is a protective compound produced by grapes and other plants in response to
environmental stresses. Studies have demonstrated that resveratrol has potent
antioxidant activity and also has the ability to inhibit platelet aggregation.
These actions may help prevent free radical damage throughout the body and
provide protective support to the cardiovascular system.
Red wine has about 1.5 to 3
milligrams of resveratrol per liter (a liter is almost 34 ounces).
Resveratrol 10 mg - for the certificate of analysis of this resveratrol product,
click the link below in blue
Supplement facts
Resveratrol 10 mg - extract from Hy Zhang Root Extract (Polygonum
cuspidatum)
Suggested Use: One resveratrol capsule with
breakfast a few
times a week.
Resveratrol in the news
If you haven't already heard about resveratrol,
you will shortly. This natural molecule activates a cell's survival defense
enzyme, which prolongs the time cells have to repair their broken DNA. It is not
surprising that extensive research from all over the globe indicates that resveratrol has a wide range of beneficial properties. It is anti-inflammatory,
antioxidant, anti-infective, and it activates the longevity gene. It's use is
even attributed to the curing of serious health conditions. As red wine is a
rich source of this amazing substance, many sources will reference resveratrol
as "red wine molecules," "red wine polyphenols," "red-wine extract," etc.
Unfortunately, there is a great deal of misinformation about resveratrol, so you
need to keep the following in mind when reviewing articles and marketing
information about related products. As resveratrol is found in the skins of
grapes, red wine will provide several times more resveratrol than white wine. Grape
skins are not used in the production of white wine. As resveratrol is produced
within the grape skin in response to attack by specific molds, grapes and wine
produced in moist, northern climates (where these fungi are more prevalent)
yield more resveratrol. As resveratrol is vulnerable to fairly rapid
destruction by light and oxygen, the fact that wine is stored in air-tight, cool
conditions away from sun light protects the resveratrol content. Only
immediately after a bottle of wine is opened is the maximum resveratrol potency
available.
Since wine also involves the
potential damage from alcohol and preservatives, many people prefer a dietary
supplement source for resveratrol. Another good antioxidant is
Pycnogenol.
Resveratrol article
Have you heard the hype about
resveratrol supplements helping mice live
longer? It seems this red wine ingredient is now the rage and consumers
are flocking to vitamin stores or on the internet to buy a resveratrol
supplement. Before you jump on the bandwagon, you would do yourself a
favor by getting a balanced viewpoint on this topic.
What is Resveratrol?
Resveratrol is a protective compound produced by grapes, berries, and other
plants in response to environmental stresses. A high concentration of
resveratrol is found in red wine, particularly Pinot Noir.
The Resveratrol Hype
What made resveratrol popular was a November 2006 study
published by
Harvard University researchers in
Boston that reported mice lived longer
when given a resveratrol supplement. The news media
caught up with titles such as , "Resveratrol improves health and survival of
mice on a high-calorie diet.”
How Much resveratrol is
there in red wine?
Red wine has about 1.5 to 3 milligrams of resveratrol per liter (a liter is
almost 34 ounces).
Benefits of Resveratrol
Resveratrol has potent antioxidant activity and also has the ability to inhibit
platelet aggregation. In addition, it has anti-inflammatory, anti-tumor, and
anti-infective properties. Resveratrol may even by helpful in preventing
neuronal damage in Alzheimer’s disease.
Resveratrol and
Longevity
Harvard researchers tested resveratrol on middle aged mice. Resveratrol
supplementation increased their survival. What makes this interesting is that in
previous studies over the past few years, resveratrol was found to have a
similar benefit on yeast, flies and worms. This was the first evaluation of
resveratrol on survival extension in mammals. One group of mice ate a normal
diet. The second was fed a high-calorie diet and the third had the same high
calorie diet but was given resveratrol supplements. By the time the mice were
114 weeks old, about 60 percent in the high-calorie group had died, compared to
about 40 percent in the low calorie diet group and the group with the high
calorie diet supplemented with resveratrol. The mice taking resveratrol had
healthier heart and liver tissue, decreased blood sugar levels, better insulin
sensitivity and were more active than the other rodents.
Resveratrol and Cancer
Recent laboratory studies indicate that resveratrol has promising therapeutic
activity in various cancers, including breast, prostate, and neuroblastoma.
Resveratrol Side Effects
Since human studies with resveratrol are not available, we don’t know the long
term side effects of daily use.
Availability and Dosage
Much of the resveratrol sold in supplement form is from the herb
Polygonum cuspidatum. The most common dosage is 10 mg of resveratrol per capsule
or tablet.
No one knows at this time the ideal dosage of resveratrol to take on a daily
basis, and how it would interact with other supplements or medicines. I can only
tell you that I plan to take one 10 mg capsule once or twice a week until more
research is available, and I also plan to drink one or two ounces of red wine
most evenings with dinner.
Resveratrol Antioxidant
Resveratrol is a naturally occurring stilbene derivative antioxidant having a
number of biochemical and antineoplastic effects.
Antioxidant activity of resveratrol, piceatannol and
3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines.
Oncol Rep. 2006 Sep;16(3):617-24.
Department of Mutagenesis and Carcinogenesis, Cancer Research Institute, Slovak
Academy of Sciences, 833 91 Bratislava, Slovak Republic.
trans-Resveratrol is one of the most relevant and extensively
investigated stilbenes with a broad spectrum of biological activities. In
contrast to the detailed knowledge of
trans-Resveratrol activities in biological systems,
much less is known about the effects of higher hydroxylated stilbenes.
Therefore, the aim of this study was to evaluate the antioxidant activities of
trans Resveratrol and two analogues: the natural metabolite
piceatannol (PCA) and the synthesized 3,3',4,4',5,5'-hexahydroxy-trans-stilbene
(HHS) against H2O2-induced DNA damage in leukemic L1210, K562 and HL-60 cells. In conclusion, we can prove
that all stilbenes investigated,
trans Resveratrol, PCA, and HHS, manifested potent
antioxidant effects on three leukemic cell lines.
Resveratrol and
asthma
Anti-inflammatory and anti-asthmatic effects of resveratrol, a
polyphenolic stilbene, in a mouse model of allergic asthma.
Int Immunopharmacol. 2009 Feb 7. Natural Medicine Research Center, Korea
Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusung,
Daejeon 305-600, Korea.
Asthma is an inflammatory disease of the airways, and the current focus in
managing asthma is the control of inflammation. Resveratrol may be responsible
for some of the health benefits ascribed to consumption of red wine. We
investigated the suppressive effects of resveratrol on asthmatic parameters such
as cytokine release, eosinophilia, airway hyperresponsiveness, and mucus
hypersecretion, in an OVA-induced allergic mouse model of asthma. Resveratrol
significantly inhibited increases in T-helper-2-type cytokines such as IL-4 and
IL-5 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed
airway hyperresponsiveness, eosinophilia, and mucus hypersecretion, in the
asthmatic mouse model. The efficacy of resveratrol was similar to that of
dexamethasone, a glucocorticoid used as a positive control. These results
suggest that resveratrol may have applications in the treatment of bronchial
asthma.
Resveratrol and
mitochondria
Resveratrol improves mitochondrial function and protects against metabolic
disease by activating SIRT1 and PGC-1alpha.
Cell. 2006 Dec 15;127(6):1109-22. Institut de Genetique et de Biologie
Moleculaire et Cellulaire, CNRS / INSERM / ULP, 67404 Illkirch, France.
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are
associated with reduced longevity. We tested whether resveratrol impacts
mitochondrial function and metabolic homeostasis. Treatment of mice with
resveratrol significantly increased their aerobic capacity, as evidenced by
their increased running time and consumption of oxygen in muscle fibers. The
effects of resveratrol were associated with an induction of genes for oxidative
phosphorylation and mitochondrial biogenesis and were largely explained by an
resveratrol -mediated decrease in PGC-1alpha acetylation and an increase
in PGC-1alpha activity.
Resveratrol in raw and baked blueberries and bilberries.
J Agric Food Chem. 2003 Sep 24;51(20):5867-70.
Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, Lee J, van Breemen RB.
Food and Nutritional Science Division, California State University-Long Beach,
CA
Resveratrol in the fruits of bilberry (Vaccinium myrtillus L.), the lowbush
"wild" blueberry (Vaccinium angustifolium Aiton), the rabbiteye blueberry (Vaccinium
ashei Reade), and the highbush blueberry (Vaccinium corymbosum L.) were
measured. Although blueberries and bilberries were found to contain resveratrol, the level
of this chemoprotective compound in these fruits was <10% that reported for
grapes. Furthermore, cooking or heat processing of these berries will contribute
to the degradation of resveratrol.
Mechanism of action
of resveratrol
Resveratrol activates an enzyme called SIRT1. This enzyme, in turn, suppresses
the activity of a molecule called PTP1B, which ordinarily works to decrease
insulin activity. SIRT1 levels are reduced in the animals' insulin-resistant
cells. Increasing SIRT1 activity with resveratrol improves insulin sensitivity
by acting on PTP1B. SIRT1 has a variety of functions in the body, Resveratrol supplement disease health in oxidative resveratrol stress
dose of resveratrol
Resveratrol
questions
Q. I am interested in learning if resveratrol does indeed deter fungal issues.
Quoting article by Dr Ray Saheilan: "
Fungicidal effect of resveratrol on human infectious fungi. Arch Pharm Res. 2005
May;28(5):557-60.
Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate
various biological activities on the human body. In the present study, we tested
the antifungal activity of resveratrol against human pathogenic fungi before
carrying out further studies to elucidate the antifungal mechanism(s) of
resveratrol. Resveratrol displayed potent antifungal activity against human
pathogenic fungi at concentration levels of 10-20 microg/mL. Furthermore,
time-kill curve exhibited fungicidal effect of resveratrol on Candida albicans,
but the compound had no hemolytic activity against human erythrocytes. The
destruction of C. albicans cells by resveratrol was confirmed by scanning
electron microscopy. These results suggest that resveratrol could be employed as
a therapeutic agent to treat fungal infections of humans." I am looking for more
evidence. I am having trouble locating more supporting evidence on the web. I
did find one reference from a patent application that did not support this
claim. I am anxious to be able to validate the findings and claims as I am
wanting to use this product as part of a treatment for bartonella, candida, lyme
program for myself.
A. This is all the info research we have on resveratrol and fungal
infections at this time.
Q. My question pertains to resveratrol,
and if it can induce migraines in some people. Considering the effect of red
wine on migraine sufferers, is it possible that resveratrol can have the same
effect? I just starting taking resveratrol and am noticing and intensity in the
vertigo associated with my silent migraines. I would love to keep taking it, but
I am concerned. Can you tell me if any resveratrol research has been done in
this area?
A. We are not aware of human research with resveratrol supplements
that have evaluated its role in inducing migraine headaches. Keep in mind that
most of the resveratrol that is sold as a supplement comes as part of an herbal
extract and the tablet or capsule that you ingest as a supplement also has
additional substances that are part of the herb. Whether the migraine headache
is due to the resveratrol or some of the other substances in the herbal extract
is not clear. For the time being, it may be a good idea to limit the use of a
resveratrol supplement to 2 or 3 times a week.
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