Lyprinol is a unique, stabilized marine lipid extract to provide nutritional
support for healthy joint function.• Stabilized marine lipid extract for joint support
Lyprinol Supplement
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Lyprinol
information, health benefit and use for arthritis
A mussel extract from perna canaliculus works as an
anti-inflammatory agent
The New Zealand green-lipped mussel Perna canaliculus is the source of an
extract with a product name of
Lyprinol. Claims have
been made that the preparation may be helpful in the management of inflammatory
diseases, along with asthma and various types of arthritis. There
is some evidence that mussel extracts have some anti-inflammatory capabilities,
and may potentially be helpful in asthma and arthritis and other inflammatory
conditions..
Lyprinol 50 mg
Lyprinol is a unique, stabilized marine lipid extract to provide nutritional
support for healthy joint function.
• Stabilized marine lipid extract for joint support
Lyprinol Supplement
Click
here to buy Lyprinol discount, Joint Power Rx
Lyprinol research information
Lyprinol for arthritis
A lipid-rich
extract, prepared by supercritical fluid (CO2) extraction of freeze-dried stabilized NZ
green-lipped mussel powder (Lyprinol) has shown significant anti-inflammatory (AI)
activity when given to animals and humans. When treated p.o. with Lyprinol, Wistar and
Dark Agouti rats developed neither adjuvant-induced polyarthritis or collagen(II)-induced
auto-allergic arthritis. This was achieved with doses < NSAIDs, and 200 times < of
other seed or fish oils. Lyprinol subfractions inhibited LTB4 biosynthesis by PMN in
vitro, and PGE2 production by activated macrophages. Much of this AI activity was
associated with omega-3 PUFAs and natural antioxidants [e.g. carotenoids]. In contrast to
NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does
not affect platelet aggregation [human, rat]. Clinical studies, either controlled or
randomized, have demonstrated very significant AI activity in patients with osteoarthritis
(OA), rheumatoid arthritis (RA), asthma, and other inflammatory conditions. Lyprinol is a
reproducible, stable source of bioactive lipids with much greater potency than
plant/marine oils currently used as nutritional supplements to ameliorate signs of
inflammation.
Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand
green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the
hip and knee: a multicenter 2-month clinical trial.
Cho SH, Jung YB, Seong SC, Park HB, Byun KY, Lee DC, Song EK, Son JH.
Yonsei Medical Clinic, Seoul, Korea.
Allerg Immunol (Paris). 2003 Jun;35(6):212-6.
To validate the clinical efficacy and safety of Lyprinol (a patented
extract from Perna Canaliculus), a 5-LOX inhibitor in patients with
osteoarthritis. In this multicenter trial, 60 patients with symptomatic
osteoarthritis of the knee and hip were included to receive Lyprinol at a dose
of 2 capsules twice a day. After a 4- and 8-week treatment period, the following
parameters were analyzed: visual analogue scale; Lequesne functional index;
global assessment by patients; global assessment by physician; and adverse
effects. Lyprinol treatment led to significant improvement of the signs
and symptoms of osteoarthritis as determined by all efficacy measures. After a
4- and 8-week treatment period, 53% and 80% (respectively) of patients
experienced significant pain relief, and improvement of joint function. There
was no reported adverse effect during this clinical trial. Lyprinol
was very effective and is a promising anti-inflammatory product that relieves
the signs and symptoms of osteoarthritis, without adverse effect.
Lyprinol for
Asthma
Asthma is a
chronic inflammatory disease of the airways mediated, at least in part, by leukotrienes
and other lipid mediators. Experimental studies have shown that lipid extract of New
Zealand green-lipped mussel, Perna canaliculus, is effective in inhibiting 5'-lipoxygenase
and cyclo-oxygenase pathways responsible for production of eicosanoids, including
leukotrienes and prostaglandins. The aim of this study was to assess its effect on
symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H2O2) in expired breath
condensate as a marker of airway inflammation in patients with steroid-naive asthma in a
double-blind randomised, placebo-controlled clinical trial. Forty six patients with asthma
received two capsules of lipid extract (Lyprinol) or placebo b.i.d for 8 weeks. Each
capsule of lipid extract contained 50 mg omega-3 polyunsaturated fatty acids and 100 mg
olive oil, whereas placebo capsules contained only 150 mg olive oil. There was a
significant decrease in daytime wheeze, the concentration of exhaled H2O2 and an increase
in morning PEF in the lipid extract group compared to the placebo group. There were no
significant side-effects. The authors conclude that lipid extract of New Zealand
green-lipped mussel may have some beneficial effect in patients with atopic asthma.
Lyprinol and inflammatory bowel disease
Lyprinol a potential preventive treatment for inflammatory bowel disease?
Asia Pac J Clin Nutr. 2004 Aug;13(Suppl):S94. Child Health Research
Institute, Women's & Children's Hospital, SA 5006, Australia.
Fish oil and the stabilised lipid extract of New Zealand Green Lipped Mussel (
Lyprinol trade mark ) are considered beneficial in treating arthritis and other
inflammatory conditions. Unlike fish oil, it is uncertain whether any benefit
seen with Lyprinol is due to its omega-3 fatty acid content. We compared the
effect of Lyprinol and fish oil pre-treatments on experimental induction of
inflammatory bowel disease in mice. Male C57BL/6 mice aged 6 weeks were gavaged
daily for 13 days with 150microl of olive oil, Lyprinol (5mg in OO) or fish
oil (FO, 55mg EPA/DHA). Compared with fish oil, Lyprinol treated mice had smaller
crypt area losses (distal colon), lower caecum and colon weights and a trend for
lower overall colitis severity in the distal colon. MPO activity was not
significantly affected by either Lyprinol or FO vs. OO. Conclusions- These
findings indicate that Lyprinol may be potentially useful in ameliorating
symptoms of IBD. The lack of effect of fish oil indicates that the benefit of Lyprinol
is attributable to components of the stabilised lipid extract other than its
omega 3 content. A dose-response evaluation of Lyprinol in experimental IBD is
warranted.
Lyprinol (stabilised lipid extract of New Zealand
green-lipped mussel): a potential preventative treatment modality for
inflammatory bowel disease.
J Gastroenterol. 2005 Apr. Child Health Research Institute, Women's and
Children's Hospital, North Adelaide, South Australia, Australia.
We investigated the effect of pretreatment with Lyprinol on experimentally
induced inflammatory bowel disease in mice. Our findings provide preliminary
evidence that Lyprinol may be potentially useful in ameliorating symptoms of IBD.
The benefit, however, is unlikely to be due to the omega-3 fatty acid content.
Dose-response evaluation of Lyprinol in experimental IBD is warranted.
Lyprinol supplement questions
Q. I have arthritis and plan to take Lyprinol mussel extract and I also
have fish oil softgels. Can you tell me how these two supplements compare? I
have a bottle of Omega-3 fish oil that I have been taking for about 10 days and
having great results with it.
A. The best way to find out is to try each one separately for a
couple of weeks and then decide which you like better. Some people may find the
combination is more effective. It is not possible for us to predict which will
work for you best.
Q. Can a yohimbe bark
supplement be taken along with a Lyprinol supplement?
A. Yohimbe is used only occasionally and we don't see any problems
with the occasional use of this herb along Lyprinol pills.