Gymnema sylvestre grows in South-east Asia. Its therapeutic effects for treating diabetes mellitus, rheumatic arthritis and gout have been well known for a long time. Extracts of this plant are widely used in Australian, Japananese, Vietnamese and Indian folk medicine. However, gymnema is best known for its benefits in diabetes. Gymnema helps lower blood sugar levels. Gymnema sylvestre contains compounds known as gymnemic acids and tritepenoid saponins, gymnemasins A, B, C and D. To buy Gymnema Sylvestre product.
   Gymnema sylvestre leaves have antibacterial compounds. Anti-allergic, antiviral, lipid lowering and other effects are also reported. Rodent studies indicate that gymnema may have the capacity to lower cholesterol and triglyceride levels. for more gymnema information.

What's in Gymnema?
Gymnema contains a number of saponins, and flavonoid compounds including kaempferol and quercetin.

Gymnema Sylvestre studies
Gymnema sylvestre leaf extract: a 52-week dietary toxicity study in Wistar rats
Center for Biological Safety and Research, National Institute of Health Sciences: 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
A 52-week study of oral-repeated-dose toxicity for the extraction powder of Gymnema sylvestre, Indian-native genus, Metaplexis japonica, was conducted in both genders of Wistar rats. The rats were administered a graded dose of Gymnema sylvestre at 0.01, 0.10 and 1.00% of basal powder diet, along with a group fed solely with the basal powder diet without gymnema, for 52 weeks. General conditions were recorded daily. Body weights and food consumptions were recorded weekly up to 12 weeks, and thereafter at longer intervals. At 26 weeks, for an intermediate examination, and 52 weeks, for the final examination, animals were subjected to hematology, serum chemistry, and pathological examination. None of the animals died in the period up to 52 weeks. No exposure-related changes in body-weight, in the food consumption, in the hematological examinations, or in the serum biochemical examinations were recognized. No histopathological alterations were seen. Thus, it was concluded that there was no toxic effect in rats treated with gymnema at up to 1.00% in the diet for 52 weeks. The no-observable-effect level from this study is 1.00% gymnema sylvestre, i.e., 504 mg/kg/day for male and 563 mg/kg/day for female as mean daily intake, for 52 weeks.

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