Gymnema sylvestre grows in South-east Asia. Its therapeutic effects for
treating diabetes mellitus, rheumatic arthritis and gout have been well known for a long
time. Extracts of this plant are widely used in Australian,
Japananese, Vietnamese and Indian folk medicine. However, gymnema is best known for its benefits in diabetes. Gymnema helps lower
blood sugar levels. Gymnema sylvestre contains compounds known as gymnemic acids and tritepenoid
saponins, gymnemasins A, B, C and D. To buy
Gymnema Sylvestre product.
Gymnema sylvestre leaves
have antibacterial compounds. Anti-allergic, antiviral, lipid lowering and other
effects are also reported. Rodent studies indicate that gymnema may have the
capacity to lower cholesterol and triglyceride levels. for more
gymnema information.
What's in Gymnema?
Gymnema contains a number of saponins, and flavonoid compounds including
kaempferol and quercetin.Gymnema Sylvestre
studies
Gymnema sylvestre leaf extract: a 52-week dietary toxicity study in
Wistar rats
Center for Biological Safety and Research, National
Institute of Health Sciences: 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501,
Japan.
A 52-week study of oral-repeated-dose toxicity for the extraction powder of
Gymnema sylvestre, Indian-native genus, Metaplexis japonica, was conducted in
both genders of Wistar rats. The rats were administered a graded dose of
Gymnema sylvestre
at 0.01, 0.10 and 1.00% of basal powder diet, along with a group fed solely
with the basal powder diet without gymnema, for 52 weeks. General conditions
were recorded daily. Body weights and food consumptions were recorded weekly up
to 12 weeks, and thereafter at longer intervals. At 26 weeks, for an
intermediate examination, and 52 weeks, for the final examination, animals were
subjected to hematology, serum chemistry, and pathological examination. None of
the animals died in the period up to 52 weeks. No exposure-related changes in
body-weight, in the food consumption, in the hematological examinations, or in
the serum biochemical examinations were recognized. No histopathological
alterations were seen. Thus, it was concluded that there was no toxic effect in
rats treated with gymnema at up to 1.00% in the diet for 52 weeks. The
no-observable-effect level from this study is 1.00% gymnema sylvestre, i.e., 504
mg/kg/day for male and 563 mg/kg/day for female as mean daily intake, for 52
weeks.
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