The dried fruit rind of Garcinia cambogia, also known as Malabar tamarind, is a unique source of hydroxycitric acid HCA, which has a distinct sour taste and has been used for centuries in Southeastern Asia to make meals more filling. Hydroxycitrate HCA is an active ingredient that is extracted from the rind of the garcinia cambogia fruit, which is available as an herbal supplement and promoted as a weight loss agent. Chronic administration of Hydroxycitric acid promotes lipid oxidation and spares carbohydrate utilization in mice at rest and during running.

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All natural appetite suppressant, decreases appetite so you eat less
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Natrol Pure Citrimax, Hydroxycitric Acid derived from Garcinia Cambogia
Natrol Pure CitriMax is derived from the dried rind of Garcinia Cambogia, a native fruit of India. CitriMax contains high concentrations of hydroxycitric acid, verified by HPLC to guarantee potency and quality.

Supplement Facts:
Hydroxycitric Acid HCA - 250 mg
     (Standardized extract from Garcinia cambogia fruit)

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Garcinia cambogia fruit studies
Garcinia cambogia fruit is able to decrease the acidity and to increase the mucosal defense in the gastric areas, thereby justifying its use as an anti-ulcerogenic agent.

Garcinia extract was isolated from the fruit of the Garcinia cambogia and was used as a potential antiobesity agent. In week 3 of culture with insulin, the fat cells exhibited more numerous and larger intracytoplasmic lipid droplets (i.e. 30-40 microm(2)). When Garcinia extract and insulin were added simultaneously, the accumulation of lipid droplets was inhibited and the peak droplet area shifted to become smaller (10-20 microm(2)). The activities of glycerophosphate dehydrogenase, a marker of adipose differentiation, were not significantly inhibited by the Garcinia extract. These findings suggest that the Garcinia extract inhibits lipid droplet accumulation in fat cells without affecting adipose conversion.

Garcinia article in JAMA 1998
Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase. As a citrate cleavage enzyme that may play an essential role in de novo lipogenesis inhibition, G cambogia is claimed to lower body weight and reduce fat mass in humans. To evaluate the efficacy of garcinia for body weight and fat mass loss in overweight human subjects. Twelve-week randomized, double-blind, placebo-controlled trial. Overweight men and women subjects (mean body mass index [weight in kilograms divided by the square of height in meters], approximately 32 kg/m2). Subjects were randomized to receive either active herbal compound (1500 mg of hydroxycitric acid per day) or placebo, and both groups were prescribed a high-fiber, low-energy diet. The treatment period was 12 weeks. Garcinia cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo.

Garcinia Cambogia fruit studies
Effects of (-)-hydroxycitric acid on appetitive variables.
Mattes RD, Bormann L. Purdue University, 212 Stone Hall, West Lafayette, IN 47907-1264, USA.
Physiol Behav. 2000 Oct 1-15;71(1-2):87-94.
(-)-Hydroxycitric acid (HCA) reportedly promotes weight loss, in part, through suppression of hunger. However, this mechanism has never been evaluated in humans in a controlled study. Eighty-nine mildly overweight females were prescribed 5020-kJ diets for 12 weeks as part of a double-blind, placebo-controlled parallel group study. Forty-two participants ingested 400-mg caplets of Garcinia cambogia 30-60 min prior to meals for a total dose of 2.4 g/day (1.2 g/day HCA). Forty-seven participants ingested matched placebos. Weight and body composition were assessed at baseline and every other week for 12 weeks. Food intake and appetitive variables were assessed at baseline and monthly for 12 weeks. Both groups lost body weight with the active group achieving a significantly greater reduction (3. 7+/-3.1 kg versus 2.4+/-2.9 kg). No effects of the HCA were observed on appetitive variables. The active treatment group did not exhibit better dietary compliance or significant correlations between appetitive variables and energy intake or weight change. This study does not support a satiety effect of HCA.

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