DMAE dose and benefit for mind health - DMAE study information
DMAE products for memory
Studies with DMAE go back to the 1950s. One double blind, placebo-controlled
trial performed in twenty-seven patients with severe Alzheimer's disease did not show
significant benefits (Fisman 1981). Another study on twenty-one patients with memory
deficits was also discouraging since no improvement was found in memory (Caffarra 1980).
However, DMAE was found helpful in patients with age related mental decline. DMAE was
given in a dosage of 600 mg a day for four weeks to fourteen older patients (Ferris 1977).
Ten patients improved and four were unchanged. The patients on DMAE had reduced
anxiety, and increased motivation, but they had no improvement in memory.
The researchers say, "the results thus suggest that although DMAE may not improve
memory, it may produce positive behavioral changes in some senile patients." Dementia
is a term that is now substituted for senility and is sometimes used to denote a severe
case of age related cognitive decline.
DMAE has been touted as an anti-aging nutrient but there is no proof yet that oral intake of DMAE slows aging
DMAE bitartrate 350 mg, 60 Capsules
(provides 130 mg of
Physician Formulas - Developed by Ray Sahelian, M.D.
Suggested use: Take half or one DMAE capsule in the morning with breakfast.
Click here to buy DMAE
Most people notice being more alert and focused within a couple of hours after taking DMAE. The effects can last most of the day. A few report a higher sense of wellbeing. DMAE is recommended to be taken in the early part of the day.
DMAE side effects
DMAE is available in dosages ranging from 100 to 400 mg. It is best to start with a low dose, such as 50 to 150 mg since high doses can cause anxiety, restlessness, and muscle tenseness in the neck and shoulders. DMAE taken late in the day may cause insomnia.
DMAE is usually sold by the name of DMAE bitartrate. A 351 mg pill of DMAE bitartrate yields 130 mg of actual DMAE. It is also available as liquid. One product contains 35 mg of DMAE per drop. Most users notice an effect from 60 to 150 mg of actual DMAE.
DMAE and Skin
DMAE can be helpful in the elderly who have cognitive decline. This nutrient can also be taken by an adult of any age who needs to be more focused and alert. CDP-Choline is another mind boosting supplement. DMAE cream is also available.
DMAE Enhances Mood and Alertness
There are dozens of herbs and nutrients available in health food stores that influence mental function. One that has been popular for many years is DMAE, which stands for dimethyl-amino-ethanol. A recent German study evaluated the brain's electrical reaction during presentation of videoclips of 7 minute duration in 80 subjects with borderline emotional disturbance. The researchers recorded the different emotional states by having the subjects watch these film excerpts. Half of the subjects were then started on a daily dose of DMAE and the testing was repeated after 6 and 12 weeks. The testing included showing the videoclips, filling out mood questionnaires, and also evaluating the brain's electrical reaction through EEGs (electrodes placed on the scalp that measure brain activity) . The results showed that those who took the DMAE daily had less of a decrease in theta and alpha1 brain electrical activity indicating that they were more alert. Furthermore, the questionnaires revealed that those on DMAE had a better mood. The researchers conclude, "DMAE can be interpreted to induce a psychophysiological state of better feeling of wellbeing on both levels of analysis mood and electrical pattern of brain activity in subjects suffering from borderline emotional disturbance."
Comments: Most people notice being more alert and focused within a couple of hours after taking DMAE. DMAE is available in dosages ranging from 100 to 400 mg. It is best to start with a low dose, such as 50 to 150 mg of actual DMAE since high doses can cause anxiety, restlessness, and muscle tenseness in the neck and shoulders. DMAE taken late in the day may cause insomnia.
Q. Does DMAE actually decreases lifespan in adults? I heard in this bulk nutrition website that DMAE helps lifespan in Japanese quails.
A. There is no proof in humans that DMAE use helps a person live longer. No such DMAE studies have been done.
Q. Iv'e tried DMAE and like it's effect on my mind, but I
found a study recently which stirred me up:
The lysosome hypothesis of aging predicts that membrane stabilizers will extend life-span. Stabilizers containing the dimethylaminoethanol moiety (DMAE) have been reported to extend the life-span of drosophila and mice. We tested the prediction in Japanese quail (N = 15) by administering DMAE bitartrate (18.4 mg/kg/day) in the drinking water for 69 weeks, starting at 195 weeks of age. A matched control group (N = 14) received tartaric acid (4.0 mg/kg/day) in the water. Contrary to the prediction, the DMAE-treated group has a shorter life-span after start of treatment (49 weeks) than the controls (69 weeks). No significant differences between the groups were observed in body weight or daily fluid intake. Three behavioral studies were carried out on survivors at 243-249 weeks of age, namely; activity response to light-flash; sexual mounting response to a female quail; and classical conditioning of the heart rate. Aged quail differed from young-adults in changes in motor activity in response to light flashes. Aged quail appeared less responsive initially to reinforced conditioning trials and demonstrated extinction when light flash was not followed by electric shock. There were no detectable differences in latency to mount or in basal heart rate, either as a function of age or as a function of DMAE treatment.
A. We try not to rely too heavily on animal studies since the dosages used on animals is often not the dosage that human use. Even a moderate difference in DMAE dosage can make a huge difference in how this supplement affects the body.
I'm quite worried about the long-term side effects, to say the least.
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