CoQ10 product for sale in different doses
Benefit of CoQ10 cancer treatment, energy enhancement and coq10 side effects, risks

CoQ10 is a naturally occurring nutrient found in each cell of the body. CoQ10 was first identified by University of Wisconsin researchers in 1957. CoQ10 is found in foods, particularly in fish and meats. In addition to playing a significant role in the energy system of each of our cells, CoQ10 is a good antioxidant. Many who take CoQ10 notice that this nutrient enhances energy and mental clarity. This supplement is also known as ubiquinone.

For which conditions is CoQ10 helpful?
Studies with CoQ10 have mostly focused on its role in improving certain types of cardiovascular diseases, including congestive heart failure and hypertension. However, CoQ10 may also benefit those with diabetes and Parkinson's disease. The role of CoQ10 in cancer prevention or treatment is still being evaluated.

CoQ10 on sale -- CoQ10-30mg, 50 mg, 60 mg

CoQ10 - 50 mg, 60 softgels



CoQ10 - 100 mg, 60 softgels
 

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How does CoQ10 work in the body?
Each cell in the body needs a source of energy to survive, so cells break down sugars, fats, and amino acids to make energy. Small enclosures within cells that make this energy are called mitochondria. CoQ10 exists naturally in our mitochondria and carries electrons involved in energy metabolism. CoQ10 is essential in the production of adenosine triphosphate (ATP), the basic energy molecule of each cell.
   In the bloodstream, CoQ10 is mainly transported by lipoproteins such as LDL (low-density lipoprotein) and HDL (high-density lipoprotein). It is thought that CoQ10 is one of the first antioxidants to be depleted when LDL is subjected to oxidation. Hence, CoQ10 is an important nutrient that prevents the oxidation of lipoproteins, thus potentially reducing the risk of arteries from forming plaques and getting damaged.
   In healthy individuals, CoQ10 is found in high concentrations in the heart, kidneys, and liver.

Studies with CoQ10 supplements
Diabetes: CoQ10 may be beneficial in diabetics. It helps improve the function of endothelial cells lining blood vessels and may slightly help with blood sugar control. 

Heart Attacks: In a small trial of patients with recent myocardial infarction, CoQ10--used in addition to aspirin and cholesterol-lowering drugs--decreased the likelihood of further cardiac events for at least one year after the heart attack. The dosage of CoQ10 used in the study was 60 mg twice daily.

Heart Failure: One study in patients with heart failure showed significant improvement in functional status, clinical symptoms, and quality of life in end stage heart failure patients who were placed on CoQ10 (see bottom of page). CoQ10 may be helpful for some people with heart disease.

Hypertension: CoQ10 may help lower blood pressure by a small amount.

CoQ10 and Drug interactions
The administration of CoQ10 and warfarin does not significantly affect the anticoagulant effect of warfarin in rats. A Human trial shows Co Q10 and Ginkgo biloba do not influence the clinical effect of warfarin.

Side Effects and Cautions, danger and risk
High dosages of CoQ10 can induce restlessness and insomnia but no mortality has been reported with the use of this energy enhancing supplement.

CoQ10 studies
Parkinson's Disease: A small but promising study found that coenzyme CoQ10 may help stop the nerve cell death that characterizes Parkinson's. disease. The study involved just 80 people. Half ate maple-nut flavored wafers containing various CoQ10 doses, half took a placebo for up to 16 months. By the study's end, the 23 patients on the highest daily doses had 44 percent less decline in mental function, movement and ability to perform daily living tasks than the placebo group. Research has suggested that energy-supplying structures inside cells called mitochondria may be impaired in Parkinson's disease. Patients studied had early-stage Parkinson's and took a placebo or CoQ10 in doses of 300 milligrams, 600 mgs or 1,200 mgs daily. Their symptoms were evaluated for up to 16 months. By the eighth month, the 23 patients on the highest dose showed significantly less impairment than the others. Side effects, including back pain, headaches and dizziness, were mostly mild.
    Comments: We are surprised these patients could tolerate these very high doses of CoQ10. I have had feedback from those using high doses of CoQ10 that, in some people, there is excessive stimulant-like effect and high levels of alertness that may cause insomnia.

CoQ10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study.
Berman M, Erman A. Heart-Lung Transplant Unit, Rabin Medical Center, Beilinson Campus, Potah Tikva, Israel.
Clin Cardiol. 2004 May;27(5):295-9.
The number of patients awaiting heart transplantation is increasing in proportion to the waiting period for a donor. Studies have shown that coenzyme Q10 (CoQ10) has a beneficial effect on patients with heart failure. HYPOTHESIS: The purpose of the present double-blind, placebo-controlled, randomized study was to assess the effect of CoQ10 on patients with end-stage heart failure and to determine if CoQ10 can improve the pharmacological bridge to heart transplantation. A prospective double-blind design was used. Thirty-two patients with end-stage heart failure awaiting heart transplantation were randomly allocated to receive either 60 mg U/day of Ultrasome--CoQ10 (special preparation to increase intestinal absorption) or placebo for 3 months. All patients continued their regular medication regimen. Assessments included anamnesis with an extended questionnaire based partially on the Minnesota Living with Heart Failure Questionnaire, 6-min walk test, blood tests for atrial natriuretic factor (ANF) and tumor necrosis factor (TNF), and echocardiography. Twenty-seven patients completed the study. The study group showed significant improvement in the 6-min walk test and a decrease in dyspnea, New York Heart Association (NYHA) classification, nocturia, and fatigue. No significant changes were noted after 3 months of treatment in echocardiography parameters (dimensions and contractility of cardiac chambers) or ANF and TNF blood levels. The administration of CoQ10 to heart transplant candidates led to a significant improvement in functional status, clinical symptoms, and quality of life. However, there were no objective changes in echo measurements or ANF and TNF blood levels. Coenzyme Q10 may serve as an optional addition to the pharmacologic armamentarium of patients with end-stage heart failure. The apparent discrepancy between significant clinical improvement and unchanged cardiac status requires further investigation.

Serum coenzyme Q10 concentrations in healthy men supplemented with 30 mg or 100 mg coQ10 for two months in a randomized controlled study.
Zita C, Overvad K, Mortensen SA.Clinic of Geographic Medicine, Prague, Czech Republic.
Biofactors. 2003;18(1-4):185-93.
Serum CoQ10 concentrations were evaluated in healthy male volunteers supplemented with 30 mg or 100 mg CoQ10 or placebo as a single daily dose for two months in a randomized, double-blind, placebo-controlled study. Median baseline serum CoQ10 concentration in 99 men was 1.26 mg/l (10%, 90% fractiles: 0.82, 1.83). Baseline serum CoQ10 concentration did not depend on age, while borderline significant positive associations were found for body weight and smoking 1-10 cigarettes/d. Supplementation with 30 mg or 100 mg CoQ10 resulted in median increases in serum CoQ10 concentration of 0.55 mg/l and 1.36 mg/l, respectively, compared with a median decrease of 0.23 mg/l with placebo. The changes in the CoQ10 groups were significantly different from that in the placebo group, and the increase in the 100 mg CoQ10 group was significantly greater than that in the 30 mg CoQ10 group. The change in serum CoQ10 concentration in the CoQ10 groups did not depend on baseline serum CoQ10 concentration, age, or body weight.

CoQ10 product questions
Q. Dr. Sahelian on his website seems to be concerned about using high dosages of CoQ10. In regard to CoQ10 dosage. I see a lot of people with cancer and a Danish Doctor who has been doing a lot of research with coq10 and cancer found that they needed 400mg daily to get any real benefit from Q10. I have had people on coQ10  for at least 2 years on that dosage & never seen a side effect of any kind All my adult cancers take this CoQ10 dosage.
   A. When people take CoQ10 in high dosages as a daily supplement for many years or decades, we have no idea whether this will interfere with their metabolism. It is unnatural to expose the body to such high dosages. What if we learn 20 years from now that people taking more than 200 mg a day of CoQ10 actually live a few years shorter or somehow their mitochondria are not functioning as well? As with hormone replacement therapy, it took decades for the scientific community to find out that it caused more problems than in solved. CoQ10 appears to be a healthy supplement, but who knows for certain that taking more than 100 mg is healthier than taking less? If there is still no such proof, then one should be cautious and take less, not more. Many people who take CoQ10 also take other supplements or medicines and we have no idea the interactions that could be caused. Plus, what if someone who is used to taking 400 mg a day goes on a trip and forgets their bottle and in the foreign country they can't find CoQ10? If, after years of taking 400 mg their body is used to it, what happens if they stop? What if when they are older and they are on a limited budget they can't afford buying CoQ10 anymore? There are many answers about high dose CoQ10 use that we don't know yet. We also have reports from quite a few people who actually feel fatigued when they take more than 100 mg of CoQ10. Perhaps high doses of CoQ10 for cancer or other conditions is appropriate, but for the general public taking CoQ10 as a healthy supplement, there is no proof that taking more is a healthy thing to do. We also have to consider the cost, CoQ10 is very expensive.

Q. My mother has been diagnosed with PSP. Over the past year she has gone down hill fast showing most if not all of the PSP symptoms. I do research nightly on the internet and CoQ10 came across some reading the other night. I am interested in what you feel would be a good starting dosage for my mom. At this point trying anything that might “buy” her some time is important to me. Sadly with how PSP is affecting her, she has all of her mental functions….she talks slow and often times in a slur, but what she says is accurate. What she is losing is the ability to see, walk, and write. I would like to put her on the supplement and see what it does for her. She deserves some quality of life. Progressive supranuclear palsy (PSP) is a rare brain disorder that causes serious and permanent problems with control of gait and balance.
   A. We understand how difficult it is to have a mother with this condition, but we cannot give individual advice on treatment. We can only suggest, as a general guideline, to start with low dosages and have guidance by your doctor.

Q. I was taking bacopa capsules for a few years and decided to take COQ10 this past couple months, so not knowing if I could take both I went off the bacopa. I love the energy COQ10 provides me but I miss the mental clarity benefits of the bacopa. Can I take CoQ10 and bacopa together?
   A. We are not aware of any studies that have combined bacopa herb supplements and CoQ10. As a general rule, most supplements can be combined if their dosages are kept low. However, each person reacts differently, so no general statements can be made that would apply to everyone.

Q.  After reading the recap on CoQ10 regarding strength of dosage and overdosing I have a concern. My doctor has recommended 100mg two times a day to accompany the statin drug Crestor which I am taking. Should I be concerned that this CoQ10 dosage may be too much to take on a daily basis.
   A. Different doctors have different opinions on this topic. We prefer using a lower dosage.

CoQ10 and cholesterol
CoQ10 is a naturally occurring nutrient found in each cell of the body. CoQ10 is found in foods, particularly in fish and meats. In addition to playing a significant role in the energy system of each of our cells, .
studies with CoQ10 have mostly focused on its role in improving certain types of cardiovascular diseases, including congestive heart failure and hypertension. Many who take CoQ10 notice that this nutrient enhances energy.
To examine the effect of coenzyme Q10 supplementation on blood cholesterol, subjects with clinical diagnosis of acute myocardial infarction and angina pectoris were randomized to either coenzyme Q10 or placebo for a period of 28 days. Cholesterol levels showed a reduction in the coenzyme Q10 group compared with the placebo group, with a net reduction of 22% attributed to coenzyme Q10. Coenzyme Q10 has also been shown to be an excellent antioxidant, and could prevent cholesterol from being oxidized in the bloodstream. Some studies indicate that Co!0 levels in the blood are lowered when people take statin drugs. Therefore, one could consider adding CoQ10 when taking these drugs.

CoQ10 supplement - how is CoQ10 made - synthetic or natural?
Q. How is CoQ10 made, are most CoQ10 supplements on the market synthetically produced or do they come from a natural source?
   A. CoQ10 is made synthetically and there are dozens of labs across the country and different parts of the world that have their own methods of making CoQ10 and they are not willing to share their exact steps to prevent competing manufacturers from learning their methods. The importance is the final result and purity which is tested by HPLC. Therefore it is not important to know the various biochemical steps used to make CoQ10, but to be sure the final product meets the independent HPLC test and purity requirements.

CoQ10 supplement information
Q. Are some companies still making CoQ10 from animal hearts?
   A. No, CoQ10 is made synthetically in a laboratory.

For CoQ10, what is the difference between Physician Formulas and Club Natural? Also, I want to order Diet Rx in addition to CoQ10. Can I take these two products together? If so, what time of day?
    We suggest taking them separately since there could be too much energy combining them unless the dosages are low. Diet Rx can be taken before breakfast or before lunch. CoQ10 supplements are taken in the morning.

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