Chitosan is extracted from the shells of crustaceans, such as shrimp and crab. Chitosan is not digestible but may have beneficial effects on the gastrointestinal tract. Chitosan appears to reduce the absorption of bile acids or cholesterol; either of these effects may cause a lowering of blood cholesterol. This effect has been demonstrated in animals, and a preliminary human study showed that 3–6 grams per day of chitosan taken for two weeks resulted in a 6% drop in cholesterol and a 10% increase in HDL (the “good”) cholesterol.  For more info see www.raysahelian.com.
   A combination of hoodia, ginger, cinnamon, green tea extract, spirulina, acetylcarnitine, choline, guggul, and several other herbs and nutrients, as found in Diet Rx, a very effective herbal diet pill for weight loss. Users of Diet Rx have lost several pounds within a week or two. Diet Rx does not have chitosan.

Chitosan supplement 500 mg

Chitosan, a fiber derived from chitin in shell-fish, is a nondigestible aminopolysaccharide. Chitosan is synthesized by removing acetyl groups from chitin, through a process called deacetylation. This process enhances the activity of chitosan by improving its solubility in the acidic environment of the stomach.

Chitosan Supplement Facts:
Chitosan (minimum 90% deacetylated chitin) 500 mg

Suggested Use: Two chitosan capsules before lunch and two capsules before dinner. Drink at least 4 glasses of fluid daily.
* Chitosan daily value not established
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Chitosan Summary
Studies evaluating the role of chitosan in weight loss have produced mixed results. We are not ready to endorse the use of chitosan at this time.

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Supplements that could suppress appetite, help with weight loss, or improve metabolic syndrome. Many of these are found in a product called Diet Rx
Bitter orange also known as Citrus-Aurantium, Ginger root (Zingiber officinalis), Green-Tea-Extract (Camellia sinensis, standardized to contain 50% polyphenols), Spirulina (Spirulina platensis), Hoodia-Extract (Hoodia gordonii, 20 to 1 extract), CLA fatty acids, Cinnamon root (Cinnamomum cassia), Apple Cider vinegar, Apple pectin, Garcinia cambogia CitriMax HCA-600 SXS (standardized to contain 60% hydroxycitric acid), Glucomannan konjac 4 to 1 extract, Alpha-Lipoic, Grapefruit extract (Citrus paradise, 4 to 1 extract), Acetyl-l-Carnitine. Banaba extract (standardized to contain 1 % corosolic acid), 5-HTP, Choline bitartrate, Inositol, Carnitine (Hcl), Pomegranate (standardized to contain 40 % ellagic acid), Bitter melon extract (Momordica charantia), Psyllium husk, Coleus forskohlii (standardized to contain 10 % forskohlin), Fenugreek seed extract 4 to 1 (Trigonella foenum), Guggul herb (standardized to contain 10 % guggulsterones), and Inulin. Other products to consider include chitosan. We don't think guarana and the alkaloid ephedra are good choices.

Chitosan studies
Efficacy of a novel chitosan formulation on fecal fat excretion: a double-blind, crossover, placebo-controlled study.
Barroso Aranda J. Oasis of Hope Hospital, Tijuana, Baja California, Mexico.
J Med. 2002;33(1-4):209-25.
The ability of a novel chitosan formulation to influence gastrointestinal fat absorption in vivo was examined in a double-blind, placebo-controlled, crossover study by determining the content of total fat in feces in two groups of subjects. Twenty-nine normal healthy subjects were recruited for the study. Twenty-four participants completed the test period with the chitosan formulation, and 21 completed the placebo phase of study. During the placebo and the test periods, the subjects were administered six capsules three times daily 10 minutes before meals for three days and for the two days of the stool collection. A daily serving of six tablets of the test compound contained 2100 mg chitosan and 300 mg psyllium husk seeds. In respect to the baseline period, the test compound increased fat excretion significantly whether the test period preceded or proceeded the placebo period (p<0.02 and p<0.05 respectively). In contrast, essentially no changes were seen during the placebo loading periods. Compared to the difference between placebo period and its baseline period, a statistically significant increase in fecal fat excretion was observed over baseline following oral supplementation of a novel formulation of chitosan and psyllium husk seeds. The average daily increase in fecal fat of 3-4 grams over control could account for a decrease in calorie consumption of 30-40 kcal per day. A total of 19 subjects completed both parts of the study. Examining the data from these 19 subjects by ANOVA, it was found that the period when the test compounds were given was statistically significantly different from the placebo baseline, placebo experimental, and test baseline periods. Using multiple comparisons, it was ascertained that the novel formulation containing chitosan plus psyllium husk seeds increases fecal fat excretion.

Effect of chitosan in complex management of obesity [Article in Polish]
Zahorska-Markiewicz B. Katedra Patofizjologii Sl. AM w Katowicach.
The aim of the present study was to verify the effect of chitosan as a possible adjuvant in the complex management of obesity. Fifty obese women (22-59 years, BMI > 30) participated in the study. A six months program consisted of 2-hour meetings with a physician, psychologist and dietitian, in a group of about 20 persons, every two weeks. Low calorie diet (1000 kcal/day), physical activity and behaviour modification were recommended. Supplementation with chitosan was evaluated in a randomized, placebo-controlled, double-blind study. In the chitosan group, participants received ChitininN (Primex Ingredients ASA, Avaldsnes, Norway) i.e. 750 mg pure chitosan per tablet, two tablets three times daily before each main meal. The placebo group received identical placebo tablets. RESULTS: Significantly higher body weight loss was noted in the chitosan-supplemented group (15.9 kg) than in the placebo group (10.9 kg) Also a greater decrease of systolic and diastolic blood pressure was observed in the chitosan group. There was no difference between the groups in the decrease of LDL and total cholesterol. No adverse effects were noted but the number of drop-outs was higher in the placebo group than in the chitosan group. CONCLUSION: Chitosan can be used as a valuable and safe adjuvant in long-term dietary treatment of obesity. Chitosan seems to accentuate the reduction of blood pressure associated with weight reduction.

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