Alzheimer's statistics
The
rate of Alzheimer's disease has increased substantially
from past estimates, with 67 out of 1,000 Americans over the age of 65 affected. Recent US census
statistics
suggest that by 2050, the number of people with Alzeimer's disease will triple.
Alzheimer's prevention -
copper
High copper levels in tap water may play a
role in causing Alzheimer's disease. Those at risk for Alzheimer's (i.e. family history)
may consider drinking distilled water.
Alzheimer's prevention - healthy
vegetable juices
Preventing Alzheimer's disease may be possible by drinking
more vegetable and fruit juices, particularly vegetable juices since they have
less fructose. These juices have tons of beneficial
antioxidants.
Alzeimer's prevention -
lower homocysteine, use folate and B vitamins
The controversy continues regarding the role of homocysteine in causing
Alzheimer's disease and whether the use of B vitamins are effective for
Alzheimer's prevention. Findings from a longitudinal study indicate an inverse association
between folate intake and the risk of Alzheimer's disease. There is evidence
that elevated homocysteine levels may raise the risk of Alzheimer's disease,
says Dr. Jose A. Luchsinger, from Columbia University Medical Center in New
York. In their study, reported in the Archives of Neurology for January, the
researchers assessed the occurrence of Alzheimer's disease in 965 dementia-free
older adults who completed a food frequency questionnaire and then were followed
for 6 years, on average. Dietary and supplemental folate, vitamin B6, and
vitamin B12 intake were estimated from the questionnaire responses. A total of
192 subjects were diagnosed with Alzheimer's disease during follow-up. Subjects
in the highest quartile of folate intake (at least 487 µg/day) were 50% less
likely to develop Alzheimer's disease than those in the lowest quartile (no
greater than 293 µg/day), the report indicates. By contrast, levels of vitamin
B6 and B12 were not associated with the risk of Alzheimer's disease.
Interestingly, high folate intake was only "modestly associated with lower
homocysteine levels," Dr. Luchsinger noted, "suggesting that other mechanisms
may be involved" in the possible anti-Alzheimer's effect. Archives of Neurology
2007;64:86-92.
Alzheimer's prevention with
fish oils?
The following study shows slight benefit in preventing or reducing Alzheimer's
in some patients. Could a higher dose have worked better? Could nutritional
therapy be more effective in
early Alzheimer's?
Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer
disease: OmegAD study: a randomized double-blind trial.
Arch Neurol. 2006 Oct;63(10):1402-8. Department of Neurobiology, Caring
Sciences and Society, Section of Clinical Geriatrics, Karolinska University
Hospital Huddinge, Stockholm.
Two hundred four patients with
Alzheimer's disease
whose conditions were stable while receiving acetylcholine esterase inhibitor
treatment and who had a Mini-Mental State Examination (MMSE) score of 15 points
or more were randomized to daily intake of 1.7 g of docosahexaenoic acid and 0.6
g of eicosapentaenoic acid (omega-3 fatty acid-treated group) or placebo for 6
months, after which all received omega-3 fatty acid supplementation for 6 months
more. Administration of omega-3 fatty acid in patients with mild to
moderate AD did not delay the rate of cognitive decline according to the MMSE or
the cognitive portion of the Alzheimer Disease Assessment Scale. However,
positive effects were observed in a small group of patients with very mild or
early Alzheimer's disease (MMSE >27 points).
Hypertension and Alzheimer's
disease
Having hypertension reduces blood flow in the brains of Alzheimers
patients, making them more vulnerable to the effects of the disease.
Alzheimer gene
A gene that predisposes its carriers to Alzheimer's disease - APOE4 --
appears to be active only in old age and has nothing to do with mental declines
that are sometimes seen early in life.
Alzheimer's studies
Drugs for Alzheimer's
disease, which pharmaceutical companies and campaigners have lobbied the UK
government to provide to large numbers of elderly patients with dementia across
the country at a cost of over £39m a year, have little effect on their memory
and do not lead to Alzheimer's prevention and progression, according to an
important study published July 2004. The five-year study, paid for by the NHS
and not the drug companies, found that the drugs are a waste of the scarce
resources available for the condition, said the lead re searcher Roger Gray,
director of Birmingham University's clinical trials unit
Alzheimer disease test
A chemical designed by doctors in Los Angeles could give unprecedented insight
into the ravages of Alzheimer's disease and provide a new way to test for
treatments. Previously the only way to determine if a person suffers from the
devastating Alzheimer's brain ailment has been to remove some brain tissue or with an
autopsy. The new study by doctors at the University of California, Los Angeles,
is part of a larger quest to find a better method to diagnose the condition
using tracers that can be detected with a positron emission tomography, or PET,
scan. The chemical, known as FDDNP, attaches to the abnormal clumps of proteins
called amyloid plaques and tau tangles that develop in Alzheimer's sufferers and
inhibit messages being processed by the brain. Gary Small and his colleagues
discovered that the chemical allowed doctors to pick out which of 83 volunteers
had Alzheimer's, which had mild memory problems, and which were functioning
normally for their age. It was 98 percent accurate in determining the difference
between Alzheimer's and mild cognitive impairment. That was far better than the
87 percent success rate for a PET scan test that measured sugar metabolism in
the brain, and the 62 percent accuracy rate when doctors used a magnetic
resonance imaging scan to gauge brain deterioration. "You can see the telltale
FDDNP signal in people years before they get Alzheimer's," Small said. His team
also found that the distribution of the FDDNP in the brain of Alzheimer's
patients matched the pattern seen in people where the diagnosis is confirmed
with an autopsy. One problem plaguing Alzheimer's tests is that the results are
not always clear-cut. For example, some people who seem to have few memory
problems can have a positive result on a test.
Alzheimer's info help Emails
Q. I just got
Mind-Power-Rx
for my mother,
who has early stage Alzheimers' s disease. Then today I noticed an Alzheimer's article on
Galantamine. Would it be OK to give her both supplements together, or do they
have the same basic function?
A. Mind Power Rx should be tried on its own for a
month or so. After stopping Mind Power Rx for a week you can switch her to
galantamine for a month and see which works
better. It is nearly impossible to predict which supplements or drugs will be of
help to an Alzheimer's patient, but it is quite likely that nutritional therapy
can help early Alzheimer's patient retain their memory longer.
Alzheimer's prevention Alzheimer's testing Alzheimer's
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