Alpha lipoic acid is a powerful, natural antioxidant slowly becoming recognized as having some unique properties in the therapy and prevention of a broad range of diseases including diabetes and diabetic neuropathy. In addition to being a powerful antioxidant, alpha lipoic acid helps the body use glucose, hence alpha lipoic acid's potential role in improving blood sugar control. Alpha Lipoic acid is readily absorbed from the diet or as a supplement.

Buy R Alpha Lipoic Acid product - Physician Formulas

R-Alpha Lipoic Acid. R-ALA is much more potent (2 times on average) than commonly sold synthetic lipoic acid which contains both the R and S forms of lipoic acid. The S form is chemically the mirror image of the R form of lipoic acid and is not useful to the body.

Supplement Facts
R Alpha Lipoic Acid - 50 mg pill

 

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Using alpha lipoic acid on a regular basis - safety issues and side effects
Alpha lipoic acid is a very popular supplement. We used to think that high doses were safe and beneficial, but we have had reports of people noticing heart palpitations when the dosage exceeded 100 mg. It can also cause alertness late into the night. However, alpha lipoic acid is a potent water soluble and fat soluble antioxidant, plus it is beneficial for those with high blood sugar. At this point we would not suggest exceeding 50 mg of R alpha lipoic acid a day, and preferably we suggest using it only 3 or 4 times a week. Alternatively, you can open a capsule and take half a few times a week if you notice a full one being too stimulating. We've had one report of a person on thyroid medicine getting heart palpitations when they took R alpha lipoic acid and Synthroid the same day. Your dose of alpha lipoic acid should be further reduced if you are taking acetylcarnitine, acetylcysteine, or other antioxidants. There are products on the market that have a combination of acetylcarnitine and alpha lipoic acid in high doses and promote the products as having antiaging potential. We think very high dosages could be counterproductive. If supplements give you shallow sleep, that's an indication that they are too potent for you and you need to reduce the dosages.

Skin care
The number of skin care products with alpha lipoic acid is growing. The rational is that alph lipoic acid is a potent antioxidant. It inhibits cross-linking which is the formation of chemical bridges between proteins or other large molecules. Cross-linking contributed to the aging process by causing hardening of arteries, wrinkling of the skin and stiffening of joints. Many people claim that this nutrient, when applied topically,, helps to prevent and combat fine lines and wrinkles.

Dihydro-alpha-lipoic acid information
Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid.
In Vitro Cell Dev Biol Anim. 2009 May-Jun; Yamasaki M, Kawabe A, Nishimoto K, Madhyastha H, Sakakibara Y, Suiko M, Okamoto T, Suda T, Uehira K, Nishiyama K.
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuenkibanadai-nishi, Miyazaki, 889-2192, Japan.
Alpha-lipoic acid has been shown to possess cancer-cell-killing activity via activation of the apoptosis pathway. In this study, the cytotoxic activities of alpha-lipoic and dihydro-alpha-lipoic acid were compared in HL-60 cells. The cell-killing activity of dihydro-alpha-lipoic acid was higher than that of alpha-lipoic acid. Both alpha-lipoic and dihydro-alpha-lipoic acid induced caspase-3 cleavage and internucleosomal DNA fragmentation in treated cells. On the other hand, apparent necrotic or late-stage apoptotic cell populations could be detected in dihydro-alpha-lipoic acid cells but not in those treated with alpha-lipoic acid. Moreover, dihydro-alpha-lipoic acid, but not alpha-lipoic acid, induced marked mitochondrial permeability transition. Antioxidants could not prevent dihydro-alpha-lipoic- or alpha-lipoic-acid-induced cell death. In addition, dihydro-alpha-lipoic and alpha-lipoic acid did not up-regulate cellular reactive oxygen level. These results indicated that dihydro-alpha-lipoic acid exerts more potent cytotoxicity than alpha-lipoic acid through different cytotoxic actions.

Alpha lipoic acid product questions
Q. The use of alpha lipoic acid for nerve pain as a result of diabetic neuropathy, does this apply to nerve pain resulting from surgery. My wife had open heart bypass surgery and they harvested veins from the calf of one leg. Immediately after the surgery, she started having nerve pain from the knee to the foot in that leg. Doctors only seem to recommend various drugs such as Neurontin and she is highly allergic to every drug they have recommended.
   A. We have not seen research on nerve pain after surgery and the use of alpha lipoic acid.

Q. Is the use of alpha lipoic acid facial cream helpful? I've been thinking about buying a skin care product with alpha lipoic acid for wrinkle improvement.
   A. There have been a few studies that showed the use of alpha lipoic acid facial cream was beneficial to skin tissue and perhaps may help with wrinkles. Alpha lipoic acid lotion and cream are available on the internet for sale.

Q. Does alpha lipoic acid help liver function or hurt the liver?
   A. We have not come across much information on the influence of alpha lipoic acid in liver health.

Q. Can alpha lipoic acid be used together with Carnitine 500 supplement? What about alpha lipoic acid and alcar?
   A. Yes as long as the dosage of alpha lipoic acid and carnitine are kept low. Yes to the second question, also. ALCAR stands for acetyl-l-carnitine.

Q. What is the right dosage of alpha lipoic acid and diabetic neuropathy?
   A. The right dosage of alpha lipoic acid for diabetic neuropathy is still being reviewed. For the time being, a dosage of 50 mg R alpha lipoic acid seems a reasonable and cautious approach to treating diabetic neuropathy.

Q. Is alpha lipoic acid liquid better than an alpha lipoic capsule?
   A. We don't see the advantage to alpha lipoic acid liquid over a tablet or capsule.

Q. Does oral alpha lipoic acid cure acne? What about applying topical alpha lipoic acid cream on an acne scar?
   A. We doubt orally taken alpha lipoic acid has much of an influence on acne. We have not seen research with topical alpha lipoic acid cream as a treatment for acne scars.

I just started using R alpha Lipoic Acid and the dosage directions indicate to take 1 or 2 capsules of 50 mg in the morning with breakfast. However, in reading the material at another web site, I find the recommended dose is never more than 50mg or one capsule and sometimes less. I am not diabetic but do have the symptoms of neuropathy in my feet and lower legs. I have suffered from gout off and on and attribute these symptoms to the effects of those gout attacks. Can you clear this up for me?
    There are no set guidelines regarding alpha lipoic acid dosage. Some people tolerate 50 mg or 100 mg a day while others find these dosages too stimulating and prefer lower amounts. We prefer people not use alpha lipoic acid more than 50 mg a few times a week unless when this supplement is being used for a particular medical condition and under medical supervision. Heart rhythm problems have been reported on high dosages.

I want to report feeling sick to my stomach and having a racing heart two hours after taking a yohimbe bark supplement. Earlier in the day I had taken a 300 mg alpha lipoic acid pill.

My Mum has recently been told that she most probably has to have a kidney transplant. The damage is from her immunosuppressant drugs, and she's been acting like a transplant would be the only way for her to get any "better". I myself don't believe this to be the case, and was wondering if you could give me some advice regarding ALA. Being that she's currently taking 100mg of thyroxine tablets a day, what do you think would be a safe (but effective) dose of ALA for her? And if ALA does really lower thyroid levels, how much more thyroxine do you think she would need if taking 600mg of ALA a day? Don't worry, she's not going to start taking it until a doctor has prescribed it to her first. I'm just after different professional opinions on it is all. Being that most of her regular doctors probably haven't even heard of ALA, I'd like to give them more info on it than I've currently got. Speaking of doctors, what kind of health practitioner would be best for her to go to do you think? Which sort is most likely to be knowledgeable in ALA (or at least know about it), and want to prescribe it to her?
    Sorry, but we are not in a position to offer individual advice regarding treatment.