This interesting nutrient is made from the amino acid cysteine joined to an acetyl group. Acetylcysteine (also spelled N-Acetyl-L-Cysteine) is a strong antioxidant. It donates the amino acid cysteine to help form the antioxidant glutathione. Glutathione is a powerful antioxidant normally found in the body. For an excellent multivitamin.

N Acetyl Cysteine Supplement

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Side effects of acetylcysteine pills
Other than large doses causing nausea, acetylcysteine is a safe nutrient. I experienced nausea for a few minutes within an hour of taking three 600 mg pills on an empty stomach. For more details, see acetylcysteine.

Acetylcysteine Recommendations
Acetylcysteine is sold in dosages ranging from 250 to 600 mg. Acetylcysteine can help form the powerful antioxidant glutathione but the formation of glutathione synthesis is under feedback control. Administration of acetylcysteine with the resulting increase in glutathione levels may cause a feedback inhibition in glutathione synthesis. Thus, it may be best to take acetylcysteine every other day. The use of acetylcysteine certainly should be considered as an additional supplement in protecting various cells from damage in the elderly and those with Parkinson’s disease. If you are planning to use acetylcysteine along with other antioxidants, limit your daily dosage to 100 to 500 mg and don’t take it all the time. Acetylcysteine could protect the liver of those who take acetaminophen on a regular basis.

N Acetylcysteine for cocaine addiction
There is so much potential in the use of natural supplements for a number of medical conditions. It excites us when we come across research whose findings can improve the lives of so many people. Here's just one example: Researchers at the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC had 23 cocaine-dependent patients participate in a four-week study to determine if acetylcysteine supplementation would have an effect on cocaine craving. They received N-acetylcysteine at doses of 1200 mg per day, 2400 mg/day, or 3600 mg/day. All three doses were well tolerated. The majority of subjects who completed the study either stopped using cocaine completely or significantly reduced their use of cocaine during treatment. It is exciting to know that readily available and inexpensive supplements are being tested to determine their potential in reducing drug dependence - and much much more.

N Acetylcysteine and birth defects studies
Exposure of neural crest cells to elevated glucose leads to congenital heart defects, an effect that can be prevented by N-acetylcysteine.
Birth Defects Res A Clin Mol Teratol. 2006 Dec 20; Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.
Diabetes mellitus during pregnancy increases the risk for congenital heart disease in the offspring. The majority of the cardiovascular malformations occur in the outflow tract and pharyngeal arch arteries, where neural crest cells are essential for normal development. We studied the effects of specific exposure of neural crest cells to elevated glucose on heart development. Antioxidants reduce the damaging effect of glucose on neural crest cells in vitro; therefore, we investigated the effect of supplementing N-acetylcysteine in vivo. Cardiac neural crest of HH 8-12 chicken embryos was directly exposed by a single injection in the neural tube with 30 mM D-glucose (or 30 mM L-glucose as a control). To examine the effect of a reduction in oxidative stress, we added 2 mM N-acetylcysteine to the injected D-glucose. Exposure of neural crest cells to elevated D-glucose-induced congenital heart malformations in 82% of the embryos. In the embryos injected with L-glucose, only 9% developed a heart malformation. As expected, all malformations were located in the outflow tract and pharyngeal arch arteries. The frequency of heart malformations decreased from 82% to 27% when 2 mM N-acetylcysteine was added to the injected D-glucose. These data are the first to confirm that the vulnerability of neural crest cells to elevated glucose induces congenital heart malformations. The fact that N-acetylcysteine limits the teratogenicity of glucose implies that its damaging effect is mediated by an increase of oxidative stress in the neural crest cells.

Acetylcysteine pill supplement questions
Should one take these dietary supplements daily or is it okay to skip a day or two a week?
    Actually, using this product 2 or 3 times a week should be a good treatment option for most people as an antioxidant nutrient.

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