AcetylCarnitine pill
use for mental decline in middle age and old age, and how to combine it with
other brain nutrients and pills for optimal mental enhancement
Health
benefit and use in Alzeimer's disease and other neurological conditions
Acetylcarnitine (also
spelled acetyl-l-carnitine) and carnitine play several
important roles in the human body. These nutrients shuttle acetyl groups and fatty acids
into mitochondria for energy production. Without carnitine, fatty acids cannot easily
enter into mitochondria. The acetyl group of acetylcarnitine is used to form
acetyl-CoA, the most important intermediary in the generation of energy from
amino acids, fats, and carbohydrates. Therefore, acetylcarnitine serves as an
energy reservoir of acetyl groups and both acetylcarnitine and carnitine help improve energy production. The acetyl
group of acetylcarnitine is also used to make the important brain chemical
acetylcholine. Some studies suggest that perhaps acetylcarnitine can even act as a neurotransmitter itself.
Those who take carnitine pills notice an
increase in physical energy levels, but not as much mental energy. Acetylcarnitine has a significantly more
immediate and noticeable mental effect than carnitine.
Acetyl L Carnitine 300 mg each pill
.

AcetylCarnitine Supplement
Acetylcarnitine Research shows several benefits:
In aging rats, chronic administration of acetylcarnitine
increases cholinergic synaptic transmission and consequently enhances learning capacity.
The memory of aging rats is rejuvenated by giving them a combination of acetylcarnitine
and
Alpha-Lipoic acid.
Potential Benefits of Acetylcarnitine according to
published studies:
Acetylcarnitine may improve mental fatigue in those who suffer from chronic
fatigue syndrome
Patients with multiple sclerosis are helped by acetylcarnitine, which reduces
their fatigue.
Acetylcarnitine is a promising treatment for those with diabetic neuropathy
May reduce alcohol-induced cellular damage to organs.
May be helpful in geriatric patients with mild depression.
Acetylcarnitine improves the function of mitochondria, the organelles within
cells that are involved in energy production.
Is more effective than tamoxifen in the therapy of acute and early chronic Peyronie's
disease.
May help individuals with cerebellar ataxia.
Acetylcarnitine is suitable for clinical use in the prevention of neuronal death after
peripheral nerve trauma.
May be helpful in those with Alzheimer's disease.
Acetylcarnitine protects against amyloid-beta neurotoxicity.
Acetylcarnitine
short term effects
The mind boosting effect of acetylcarnitine is often noticed within a few
hours, or even within an hour. Most people report feeling mentally sharper,
having more focus and being more alert. Some find a mild mood enhancement.
Acetylcarnitine may be used as an overall mind booster. The typical dosage is 250
to 500 mg
once a day, preferably in the early part of the day. Side effects of overstimulation
or nausea may occur at dosages greater
than 300 to 500 mg.
Memory and
hypoxia
Acetyl-l-carnitine (ALCAR) prevents hypobaric hypoxia-induced spatial memory
impairment through extracellular related kinase-mediated nuclear factor
erythroid 2-related factor 2 phosphorylation.
Neuroscience. 2009 Jun 30; Barhwal K, Hota SK, Jain V, Prasad D, Singh
SB, Ilavazhagan G. Defence Institute of Physiology and Allied Sciences, Defence
Research and Development Organization, Lucknow Road, Timarpur, Delhi 110054,
India.
Exposure to hypobaric hypoxia, a condition involving decreased availability of
oxygen is known to be associated with oxidative stress, neurodegeneration and
memory impairment. The multifactorial response of the brain and the complex
signaling pathways involved therewith limits the therapeutic efficacy of several
antioxidants in ameliorating hypobaric hypoxia-induced memory impairment. The
present study was therefore aimed at investigating the potential of acetyl-l-carnitine
(ALCAR), a known antioxidant that has been reported to augment neurotrophin-mediated
survival mechanisms, in ameliorating hypoxia-induced neurodegeneration and
memory impairment. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key
transcription factor involved in the cellular defense mechanism against
oxidative stress related to brain injury and neurological disorders. The study
was designed to understand the mechanisms involving Nrf2 stabilization following
exposure to hypobaric hypoxia. The results displayed reference memory impairment
in Sprague-Dawley rats exposed to hypobaric hypoxia (7620 m) for 14 consecutive
days which however improved on administration of ALCAR during hypoxic exposure.
The study also revealed Nrf2 regulated augmented antioxidant response on
administration of ALCAR which was through a novel tyrosine kinase A (TrkA)
receptor-mediated mechanism. A decrease in free radical generation, lipid
peroxidation and protein oxidation was also observed along with a concomitant
increase in thioredoxin and reduced glutathione levels on administration of
ALCAR during exposure to hypobaric hypoxia. The present study therefore reveals
the therapeutic potential of ALCAR under conditions of hypobaric hypoxia and
elucidates a novel mechanism of action of the drug.
Inquiries
According to acetylcarnitine
studies that involved patients with Alzeimer's disease, what is the
right dosage of
acetylcarnitine to use for this cognitive disorder?
We suggest beginning with 250 mg or 300 mg a day and gradually
increasing the dosage but not exceeding 600 mg a day.
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