Acetyl-l carnitine alpha
lipoic acid and
Benefit of acetyl-l carnitine alpha lipoic acid, l acetyl-l carnitine side effects
Acetyl-l carnitine is a stabilized form of the amino acid
metabolite L Carnitine and is
utilized in the same manner in the body. acetyl-l carnitine plays an important role in
protecting and supporting brain function. For
an excellent multivitamin.
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Benefit of acetyl-l carnitine
The mind boosting effect of acetyl-l carnitine is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement. acetyl-l carnitine may be used as an overall mind booster. The typical dosage is 250 mg once a day or a few times a week.
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Additional benefit of
This nutrient may be helpful in those with Alzheimer's disease or have a form of fertility problem where acetyl-l carnitine could be useful.
Acetyl-L-Carnitine and Diabetic Neuropathy
An evaluation from two 52-week randomized placebo-controlled clinical diabetic neuropathy trials testing acetyl-l-carnitine demonstrated that acetyl-l-carnitine treatment is beneficial in alleviating symptoms (particularly pain) and improves nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy. The study was published in Diabetes Care journal.
Acetyl-l-Carnitine versus testosterone for sexual
enhancement, mood and energy
Can acetyl-l-carnitine, a natural nutrient, be just as good for aging men as testosterone? In this Italian study, a total of 120 men (age range 60 to 74) were randomized into three groups. Group 1 was given testosterone, the second group was given propionyl-L-carnitine 2 grams a day plus acetyl-L-carnitine 2 grams a day. The third group was given a placebo. Testosterone, carnitines and placebo were given for 6 months. Results: Testosterone and carnitines significantly improved performance on several tests that measure sexual function, mood, and energy. These tests included nocturnal penile tumescence, Depression Melancholia Scale score, and fatigue scale score. Carnitines proved significantly more active than testosterone in improving sexual function. Testosterone significantly increased the prostate volume and testosterone levels; carnitines did not. Carnitines and testosterone proved effective for as long as they were administered. No major side effects were reported within the 6 month study period.
Acetyl-l carnitine side effect
Side effects of acetyl-l carnitine include overstimulation at dosages greater than 500 mg. Nausea is another acetyl-l carnitine side effect.
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and testosterone for sexual health, mood and energy
Can acetyl-l-carnitine, a natural nutrient, be just as good for aging men as testosterone? In this Italian study, a total of 120 men (age range 60 to 74) were randomized into three groups. Group 1 was given testosterone, the second group was given propionyl-l-carnitine 2 grams a day plus acetyl-l-carnitine 2 grams a day. The third group was given a placebo. Testosterone, carnitines and placebo were given for 6 months. Results: Testosterone and acetyl-l-carnitine along with propionyl-l-carnitine improved performance on several tests that measure sexual function, mood, and energy. These tests included nocturnal penile tumescence, Depression Melancholia Scale score, and fatigue scale score. Acetyl-l-carnitine and propionyl-l-carnitine proved significantly more active than testosterone in improving sexual function. Testosterone significantly increased the prostate volume and testosterone levels; Acetyl-l-carnitine and propionyl-l-carnitine did not.
Comment: Acetyl-l-carnitine and propionyl-l-carnitine appeared to be slightly more effective and safer than testosterone.
for macular degeneration
Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10.
Ophthalmologica. 2005 May-Jun;219(3):154-66. Ophthalmic Neuroscience Program, Department of Ophthalmology, University of Rome 'La Sapienza', Rome, Italy.
The aim of this randomized, double-blind, placebo-controlled clinical trial was to determine the efficacy of a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10 (Phototrop) on the visual functions and fundus alterations in early age-related macular degeneration (AMD). One hundred and six patients with a clinical diagnosis of early AMD were randomized to the treated or control groups. The primary efficacy variable was the change in the visual field mean defect (VFMD) from baseline to 12 months of treatment, with secondary efficacy parameters: visual acuity (Snellen chart and ETDRS chart), foveal sensitivity as measured by perimetry, and fundus alterations as evaluated according to the criteria of the International Classification and Grading System for AMD. The mean change in all four parameters of visual functions showed significant improvement in the treated group by the end of the study period. Decrease in drusen-covered area of treated eyes was also statistically significant as compared to placebo. These findings strongly suggested that an appropriate combination of compounds which affect mitochondrial lipid metabolism, may improve and subsequently stabilize visual functions, and it may also improve fundus alterations in patients affected by early AMD.
The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery.
Kraemer WJ. University of Connecticut, Storrs, CT 06269, USA.
J Strength Cond Res. 2003 Aug;17(3):455-62.
The purpose of this investigation was to examine the influence of L-carnitine L-tartrate supplementation using a balanced, cross-over, placebo-controlled research design on the anabolic hormone response (i.e., testosterone [T], insulin-like growth factor-I, insulin-like growth factor-binding protein-3 [IGFBP-3], and immunofunctional and immunoreactive growth hormone [GHif and GHir]) to acute resistance exercise. Ten healthy, recreationally weight-trained men volunteered and were matched, and after 3 weeks of supplementation (2 g carnitine per day), fasting morning blood samples were obtained on six consecutive days (D1-D6). Subjects performed a squat protocol (5 sets of 15-20 repetitions) on D2. During the squat protocol, blood samples were obtained before exercise and 0, 15, 30, 120, and 180 minutes postexercise. After a 1-week washout period, subjects consumed the other supplement for a 3-week period, and the same experimental protocol was repeated using the exact same procedures. Expected exercise-induced increases in all of the hormones were observed for GHir, GHif, IGFBP-3, and T. Over the recovery period, carnitine reduced the amount of exercise-induced muscle tissue damage, which was assessed via magnetic resonance imaging scans of the thigh. carnitine supplementation significantly increased IGFBP-3 concentrations prior to and at 30, 120, and 180 minutes after acute exercise. No other direct effects of carnitine supplementation were observed on the absolute concentrations of the hormones examined, but with more undamaged tissue, a greater number of intact receptors would be available for hormonal interactions. These data support the use of carnitine as a recovery supplement for hypoxic exercise and lend further insights into the hormonal mechanisms that may help to mediate quicker recovery.
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Acetyl-l Carnitine questions
Q. What is acetyl-l carnitine arginate?
A. We are not familiar with acetyl- l carnitine arginate.
Q. Is headache a l acetyl-l carnitine side effect?
A. In a few people, headache may be a cause of a high dose of l acetyl- l carnitine side effect.
Q. Can you please explain to me in a simple way. I
don't have a lot of knowledge in medicine or chemical terminology. What is
the difference between the l-carnitine and the acetyl l carnithine? Are
they the same thing? If different from each other, how that difference
affects any person taking those products? Can they be taken in a
combination or make no difference either one you take? Because they are
two names for something, that looks to me like the same product; I'm kind
of confused. Basically; I know, that there is a difference on price
between these two products for whatever reason, but that's all I know.
A. Acetyl carnitine (also spelled as acetyl l carnitine or acetyl-l carnitine) and carnitine play several important roles in the human body. These nutrients shuttle acetyl groups and fatty acids into mitochondria for energy production. Without carnitine, fatty acids cannot easily enter into mitochondria. The acetyl group of acetyl l carnitine is used to form acetyl-CoA, the most important intermediary in the generation of energy from amino acids, fats, and carbohydrates. Therefore, acetyl l carnitine serves as an energy reservoir of acetyl groups and both acetylcarnitine and carnitine help improve energy production. The acetyl group of acetyl l carnitine is also used to make the important brain chemical acetylcholine. Some studies suggest that perhaps acetyl l carnitine can even act as a neurotransmitter itself. Those who take carnitine pills notice an increase in physical energy, but not as much mental energy. Acetyl l carnitine has a significantly more immediate and noticeable mental effect than carnitine because it crosses into the brain much better. The mind boosting effect of acetyl l carnitine is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement.
Q. Is it too high a dose to combine coq10 100
mg with acetyl l carnitine 500 mg?
A. For most people, yes. We suggest limiting it to CoQ10 30mg and acetyl l carnitine to 300 mg or less.
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